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Liver-derived IGF-I...
Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.
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- Sjögren, Klara, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Wallenius, Kristina, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Liu, J L (author)
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- Bohlooly-Yeganeh, Mohammad, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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Pacini, G (author)
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Svensson, L (author)
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- Törnell, Jan, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Isaksson, Olle, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Ahrén, Bo (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Diabetes. - 0012-1797. ; 50:7, s. 1539-45
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Abstract
Subject headings
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- IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice whose IGF-I gene in the liver was inactivated at 24 days of age were used to investigate the long-term role of liver-derived IGF-I for carbohydrate and lipid metabolism. Serum levels of leptin in these mice were increased by >100% at 3 months of age, whereas the fat mass of the mice was decreased by 25% at 13 months of age. The mice became markedly hyperinsulinemic and yet normoglycemic, indicating an adequately compensated insulin resistance. Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism.
Keyword
- Absorptiometry
- Photon
- Animals
- Blood Glucose
- metabolism
- Body Composition
- genetics
- Chimera
- Cholesterol
- blood
- Dietary Carbohydrates
- metabolism
- Dietary Fats
- metabolism
- Female
- Gene Silencing
- Insulin
- blood
- Insulin Resistance
- genetics
- Insulin-Like Growth Factor I
- genetics
- physiology
- Lipid Metabolism
- Liver
- chemistry
- Male
- Mice
- Mice
- Inbred C57BL
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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Sjögren, Klara, ...
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Wallenius, Krist ...
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Liu, J L
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Bohlooly-Yeganeh ...
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Pacini, G
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Svensson, L
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show more...
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Törnell, Jan, 19 ...
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Isaksson, Olle, ...
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Ahrén, Bo
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Jansson, John-Ol ...
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Ohlsson, Claes, ...
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Diabetes
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University of Gothenburg