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Obesity and disturb...
Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice.
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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Hellberg, N (author)
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- Parini, P (author)
- Karolinska Institutet
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- Vidal, Olle (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Bohlooly-Yeganeh, Mohammad, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology
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- Rudling, Mats (author)
- Karolinska Institutet
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- Lindberg, Marie K, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Warner, M (author)
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- Angelin, Bo (author)
- Karolinska Institutet
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- Gustafsson, J A (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2000
- 2000
- English.
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In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 278:3, s. 640-5
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Abstract
Subject headings
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- Clinical case reports have documented disturbances of carbohydrate and lipid metabolism in aromatase deficient and estrogen resistant males. The aim of the present study was to explore the metabolic functions of estrogens in male mice and to dissect the estrogen receptor (ER) specificity of such effects. Total body fat content and serum levels of leptin were followed in ERalpha knockout (ERKO), ERbeta knockout (BERKO), and ERalpha/beta double knockout (DERKO) mice. Neither the total body fat nor serum leptin levels were altered in any group before or during sexual maturation. However, after sexual maturation ERKO and DERKO, but not BERKO, demonstrated a clear increase in total body fat and enhanced serum leptin levels. Serum cholesterol was increased and a qualitative change in the lipoprotein profile, including smaller LDL particles, was observed in ERKO and DERKO mice. In conclusion, ERalpha but not ERbeta-inactivated male mice develop obesity after sexual maturation.
Keyword
- Adipose Tissue
- anatomy & histology
- physiopathology
- Animals
- Cholesterol
- blood
- Crosses
- Genetic
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Fatty Acids
- Nonesterified
- blood
- Female
- Heterozygote
- Insulin
- blood
- Leptin
- blood
- Lipoproteins
- blood
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Obesity
- blood
- genetics
- physiopathology
- Receptors
- Estrogen
- deficiency
- genetics
- physiology
- Sexual Maturation
- Triglycerides
- blood
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ohlsson, Claes, ...
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Hellberg, N
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Parini, P
-
Vidal, Olle
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Bohlooly-Yeganeh ...
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Rudling, Mats
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show more...
-
Lindberg, Marie ...
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Warner, M
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Angelin, Bo
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Gustafsson, J A
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show less...
- Articles in the publication
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Biochemical and ...
- By the university
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University of Gothenburg
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Karolinska Institutet