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Stunning of iodide ...
Stunning of iodide transport by (131)I irradiation in cultured thyroid epithelial cells.
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Postgård, Per (author)
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Himmelman, Jakob (author)
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- Lindencrona, Ulrika, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
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Bhogal, Nirmal (author)
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Wiberg, Dennis (author)
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- Berg, Gertrud, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
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- Jansson, Svante, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Nyström, Ernst, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Forssell-Aronsson, Eva, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
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- Nilsson, Mikael, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - 0161-5505. ; 43:6, s. 828-34
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Abstract
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- The existence of thyroid stunning (i.e., inhibited thyroidal iodide uptake after administration of diagnostic amounts of (131)I) is controversial and is currently a subject of debate. To our knowledge, the stunning phenomenon has not been investigated previously in vitro. METHODS: Growth-arrested porcine thyroid cells that formed a tight and polarized monolayer in a bicameral chamber were irradiated with 3-80 Gy (131)I present in the surrounding culture medium for 48 h. The iodide transport capacity after irradiation was evaluated 3 d later by measuring the transepithelial (basal to apical) flux of trace amounts of (125)I. RESULTS: The basal-to-apical (125)I transport decreased with increasing absorbed dose acquired from (131)I; a nearly 50% reduction was observed already at 3 Gy. Stable iodide at the same molarity as (131)I (10(-8) mol/L) had no effect on the (125)I transport. Cell number and epithelial integrity were not affected by irradiation. CONCLUSION: Stunning of iodide transport is detected after (131)I irradiation of cultured thyroid cells. The degree of inhibition of transport is dependent on the absorbed dose.
Keyword
- Animals
- Biological Transport
- Cells
- Cultured
- Iodides
- pharmacokinetics
- Iodine Radioisotopes
- Radiation Dosage
- Swine
- Thyroid Gland
- cytology
- radiation effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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Postgård, Per
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Himmelman, Jakob
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Lindencrona, Ulr ...
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Bhogal, Nirmal
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Wiberg, Dennis
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Berg, Gertrud, 1 ...
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show more...
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Jansson, Svante, ...
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Nyström, Ernst, ...
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Forssell-Aronsso ...
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Nilsson, Mikael, ...
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- Articles in the publication
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Journal of nucle ...
- By the university
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University of Gothenburg