Search: onr:"swepub:oai:gup.ub.gu.se/78823" >
Amyloid-related bio...
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Andreasen, NielsKarolinska Institutet
(author)
Amyloid-related biomarkers for Alzheimer's disease.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Bentham Science Publishers Ltd.2008
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/78823
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https://gup.ub.gu.se/publication/78823URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:116845548URI
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https://doi.org/10.2174/092986708783955572DOI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Alzheimer's disease (AD) is an age-related disorder that causes brain damage resulting in progressive cognitive impairment and death. Three decades of progress have given us a detailed understanding of the underlying molecular mechanisms. Over the past 10 years, this knowledge has translated into a range of targets for therapy, the most promising of which is amyloid beta (Abeta). An imbalance between the production and clearance of Abeta is thought by many to represent the earliest event in the pathogenesis of AD. Abeta is known to be subject to oligomerisation, a process that increases its synaptotoxicity. The oligomers may aggregate further to proto-fibrils and fibrils, eventually forming senile plaques, the neuropathological hallmark of AD. In this article we review the key aspects of Abeta as a biomarker for AD, including its pathogenicity, the diagnostic performance of different Abeta assays in different settings, and the potential usefulness of Abeta as a surrogate marker for treatment efficacy in clinical trials of novel Abeta-targeting drugs.
Subject headings and genre
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Alzheimer Disease
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metabolism
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pathology
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Amyloid beta-Protein
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metabolism
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Animals
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Biological Markers
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metabolism
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Humans
Added entries (persons, corporate bodies, meetings, titles ...)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
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In:Current medicinal chemistry: Bentham Science Publishers Ltd.15:8, s. 766-710929-8673
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