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Endothelium-specifi...
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
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- Bjarnegård, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Enge, Maria, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Norlin, Jenny (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Gustafsdottir, Sigrun (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Fredriksson, Simon (author)
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- Abramsson, Alexandra, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Takemoto, Minoru (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Gustafsson, Erika (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Fassler, Reinhard (author)
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- Betsholtz, Christer, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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(creator_code:org_t)
- The Company of Biologists, 2004
- 2004
- English.
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In: DEVELOPMENT. - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 131:8, s. 1847-1857
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Abstract
Subject headings
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- Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development, but the relative importance of different cellular sources of PDGFB has not been established. Using Cre-lox techniques, we show here that genetic ablation of Pdgfb in endothelial cells leads to impaired recruitment of pericytes to blood vessels. The endothelium-restricted Pdgfb knockout mutants also developed organ defects including cardiac, placental and renal abnormalities. These defects were similar to those observed in Pdgfb null mice. However, in marked contrast to the embryonic lethality of Pdgfb null mutants, the endothelium-specific mutants survived into adulthood with persistent pathological changes, including brain microhemorrhages, focal astrogliosis, and kidney glomerulus abnormalities. This spectrum of pathological changes is reminiscent of diabetic microangiopathy, suggesting that the endothelium-restricted Pdgfb knockouts may serve as models for some of the pathogenic events of vascular complications to diabetes. Key words: PDGFB, Endothelium, Cre, loxP, Pericytes, Microaneurysm
Subject headings
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Keyword
- smooth-muscle-cells
- retinal vascular patterns
- protease-activated ligand
- central-nervous-system
- growth-factor
- diabetic-retinopathy
- beta-receptor
- in-vivo
- b-chain
- kidney glomeruli
- PDGFB
- Cre
- loxP
- microaneurysm
- pericytes
- endothelium
- Animals
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bjarnegård, Matt ...
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Enge, Maria, 197 ...
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Norlin, Jenny
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Gustafsdottir, S ...
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Fredriksson, Sim ...
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Abramsson, Alexa ...
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Takemoto, Minoru
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Gustafsson, Erik ...
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Fassler, Reinhar ...
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Betsholtz, Chris ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Developmental Bi ...
- Articles in the publication
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DEVELOPMENT
- By the university
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University of Gothenburg
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Lund University
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Uppsala University