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Gender differences ...
Gender differences in heritability of depressive symptoms in the elderly
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Jansson, M (author)
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Gatz, M. (author)
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- Berg, S. (author)
- Jönköping University,HHJ, Institutet för gerontologi,HHJ. Åldrande - livsvillkor och hälsa
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- Johansson, Boo (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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- Malmberg, Bo (author)
- Jönköping University,HHJ, Institutet för gerontologi,HHJ. Åldrande - livsvillkor och hälsa
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McClearn, G.E. (author)
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- Schalling, M. (author)
- Karolinska Institutet
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: PSYCHOLOGICAL MEDICINE. - 0033-2917 .- 1469-8978. ; 34:3, s. 471-479
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Abstract
Subject headings
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- BACKGROUND: The present study aimed to investigate the relative importance of genetic and environmental influences on depressive symptoms in the elderly. METHOD: Depressive symptoms were assessed through the Center for Epidemiological Studies-Depression (CES-D) scale. The CES-D scale was administered to 959 twin pairs (123 female MZs, 90 male MZs, 207 same-sex female DZs, 109 same-sex male DZs and 430 opposite-sex DZs) aged 50 years or older (mean age 72 years). A dichotomous depressed state variable was constructed based on CES-D cut-offs and self-reported use of antidepressant medication. Structural equation models were fitted to the data to dissect genetic and environmental variance components. RESULTS: The sex-specific heritability estimates for depressive symptoms were 14% for males and 29% for females and 23% when constrained to be equal for men and women. The prevalence of clinically significant depressive symptoms was 16% for men and 24% for women. Heritability estimates for the dichotomous depressed state measure were 7% for males and 49% for females in the full model and 33% when constrained to be equal. CONCLUSION: Our results suggest that depressive symptoms in the elderly are moderately heritable, with a higher heritability for women than men, although differences in heritability estimates were not statistically significant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)
Keyword
- population-ascertained subsamples
- pilot swedish twin
- older-adults
- environmental-contributions
- affective-illness
- major depression
- community
- sample
- women
- genes
- Older people and ageing
Publication and Content Type
- ref (subject category)
- art (subject category)
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