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Liposarcoma: outcom...
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Engström, Katarina,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Gothenburg Responsibility Project, Gothenburg University,Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, SE-41345 Gothenburg, Sweden
(author)
Liposarcoma: outcome based on the Scandinavian Sarcoma Group register.
- Article/chapterEnglish2008
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LIBRIS-ID:oai:gup.ub.gu.se/82582
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https://gup.ub.gu.se/publication/82582URI
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https://doi.org/10.1002/cncr.23784DOI
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https://lup.lub.lu.se/record/1286807URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117655309URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45849URI
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BACKGROUND: The aim was to study the clinicopathological characteristics, treatment, and outcome of liposarcoma in an unselected, population-based patient sample, and to establish whether treatment was according to the Scandinavian Sarcoma Group (SSG) treatment guidelines. METHODS: The SSG Pathology Board reviewed 319 liposarcoma cases reported between 1986 and 1998. After the review, 237 patients without metastasis were analyzed for local recurrence rate in relation to surgical margins, radiotherapy, occurrence of metastasis, and survival. RESULTS: Seventy-eight percent of the patients were primarily operated on at a sarcoma center, 45% with wide margins. All patients operated on outside the center had nonwide margins. Low-grade lesions constituted 67% of cases. Despite nonwide surgery, only 58% of high-grade lesions were treated with postoperative radiotherapy. The risk of local recurrence after nonwide surgery, without irradiation, was 47% for high-grade lesions. The estimated 10-year, local recurrence-free and metastasis-free survival in the low-grade group was 87% and 95%, respectively. In the high-grade group, it was 75% and 61%, respectively. Independent adverse prognostic factors for local recurrence were surgery outside a sarcoma center and histological type dedifferentiated liposarcoma. For metastases, they were old age, large tumor size, high grade, and histological type myxoid liposarcoma with a round cell component. Radiotherapy showed significant effect on local recurrence rate for the same grade and margin. CONCLUSIONS: Patients with liposarcoma should be treated at specialized centers. Postoperative radiotherapy decreases the local recurrence rate. To maintain quality and provide support for further trials, reporting to quality registers is crucial.
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Bergh, Peter,1959Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Univ Gothenburg, Sahlgrenska Acad, Dept Orthoped, SE-41345 Gothenburg, Sweden(Swepub:gu)xbergp
(author)
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Gustafson, PelleLund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Orthoped, Lund, Sweden(Swepub:lu)ort-pgu
(author)
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Hultborn, Ragnar,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, SE-41345 Gothenburg, Sweden(Swepub:gu)xhulra
(author)
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Johansson, Helena
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Löfvenberg, RickardNorrland Univ Hosp, Dept Orthoped, Umea, Sweden
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Zaikova, OlgaNorwegian Radium Hosp, Dept Orthoped, Oslo, Norway
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Trovik, ClementHaukeland Hosp, Dept Orthoped, N-5021 Bergen, Norway
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Wahlström, OlaÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Ortopedi och idrottsmedicin,Ortopedkliniken Linköping(Swepub:liu)olawa48
(author)
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Bauer, Henrik C FKarolinska Institutet,Karolinska Hosp, Dept Orthoped, S-10401 Stockholm, Sweden
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
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In:Cancer: Wiley113:7, s. 1649-560008-543X1097-0142
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