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Transplantation of ...
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation.
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- Brederlau, Anke, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Correia, Ana Sofia (author)
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- Anisimov, Sergey (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Elmi, Muna, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Paul-Visse, Gesine (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Roybon, Laurent (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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Morizane, Asuka (author)
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Bergquist, Filip, 1970 (author)
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Riebe, Ilse, 1978 (author)
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- Nannmark, Ulf, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Carta, Manolo (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
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- Hanse, Eric, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Takahashi, Jun (author)
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Sasai, Yoshiki (author)
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- Funa, Keiko, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Brundin, Patrik (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Eriksson, Peter S, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Li, Jia-Yi (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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(creator_code:org_t)
- 2006-03-23
- 2006
- English.
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In: Stem cells (Dayton, Ohio). - : Oxford University Press (OUP). - 1066-5099 .- 1549-4918. ; 24:6, s. 1433-40
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Human embryonic stem cells (hESCs) have been proposed as a source of dopamine (DA) neurons for transplantation in Parkinson's disease (PD). We have investigated the effect of in vitro predifferentiation on in vivo survival and differentiation of hESCs implanted into the 6-OHDA (6-hydroxydopamine)-lesion rat model of PD. The hESCs were cocultured with PA6 cells for 16, 20, or 23 days, leading to the in vitro differentiation into DA neurons. Grafted hESC-derived cells survived well and expressed neuronal markers. However, very few exhibited a DA neuron phenotype. Reversal of lesion-induced motor deficits was not observed. Rats grafted with hESCs predifferentiated in vitro for 16 days developed severe teratomas, whereas most rats grafted with hESCs predifferentiated for 20 and 23 days remained healthy until the end of the experiment. This indicates that prolonged in vitro differentiation of hESCs is essential for preventing formation of teratomas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Cell Differentiation
- Cell Proliferation
- Cell Survival
- Female
- Humans
- Neurons
- pathology
- Parkinsonian Disorders
- pathology
- physiopathology
- therapy
- Rats
- Rats
- Sprague-Dawley
- Stem Cell Transplantation
- adverse effects
- Teratoma
- etiology
- prevention & control
- Transplantation
- Heterologous
- human embryonic stem cells
- neural transplantation
- disease
- Parkinson's
- dopaminergic neurons
- differentiation
- teratoma formation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brederlau, Anke, ...
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Correia, Ana Sof ...
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Anisimov, Sergey
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Elmi, Muna, 1978
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Paul-Visse, Gesi ...
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Roybon, Laurent
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show more...
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Morizane, Asuka
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Bergquist, Filip ...
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Riebe, Ilse, 197 ...
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Nannmark, Ulf, 1 ...
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Carta, Manolo
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Hanse, Eric, 196 ...
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Takahashi, Jun
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Sasai, Yoshiki
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Funa, Keiko, 194 ...
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Brundin, Patrik
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Eriksson, Peter ...
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Li, Jia-Yi
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Stem cells (Dayt ...
- By the university
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University of Gothenburg
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Lund University