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Microdysgenesis in ...
Microdysgenesis in surgical specimens from patients with epilepsy: occurrence and clinical correlations.
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- Nordborg, Claes, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
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Eriksson, s (author)
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- Rydenhag, Bertil, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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- Uvebrant, Paul, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Malmgren, Kristina, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Journal of neurology, neurosurgery, and psychiatry. - 0022-3050. ; 67:4, s. 521-4
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- Malformations of cortical development are commonly associated with epilepsy. In the first 139 consecutive patients in the G?teborg epilepsy surgery series, parenchymal malformations were found in 56. 1% of the children and in 23.1% of the adults. Microdysgenesis (MDG), which was the most common parenchymal malformation, was found in 35. 1% of the children and in 16.7% of the adults. The aim of this study was to identify clinical characteristics of patients with MDG. Mental retardation was found to be significantly more common in patients with major parenchymal malformations and in patients with MDG compared with patients without parenchymal malformations. Patients with major parenchymal malformations as well as patients with MDG also had a significantly earlier onset of seizures than patients without parenchymal malformations, also when adjusting for mental retardation. Patients with MDG were in these clinical aspects shown to closely resemble patients with major malformations. These findings suggest that MDG is a pathoanatomical entity of clinical relevance, with implications both in mental retardation and in epileptogenesis.
Keyword
- Adolescent
- Adult
- Aged
- Cerebral Cortex
- abnormalities
- pathology
- Child
- Child
- Preschool
- Epilepsy
- pathology
- Female
- Humans
- Male
- Middle Aged
- Neurons
- pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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