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A magnetic resonanc...
A magnetic resonance imaging study of intestinal dilation in Trypanosoma cruzi-infected mice deficient in nitric oxide synthase.
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- Ny, Lars, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Li, Hua (author)
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Mukherjee, Shankar (author)
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Persson, Katarina (author)
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- Holmqvist, Bo (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Zhao, Dazhi (author)
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Shtutin, Vitaliy (author)
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Huang, Huan (author)
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Weiss, Louis M (author)
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Machado, Fabiana S (author)
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Factor, Stephen M (author)
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Chan, John (author)
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Tanowitz, Herbert B (author)
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Jelicks, Linda A (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: The American journal of tropical medicine and hygiene. - 1476-1645. ; 79:5, s. 760-7
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Abstract
Subject headings
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- Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract. We used magnetic resonance imaging (MRI) to monitor alterations in the GI tract of T. cruzi-infected mice, and to assess the role of nitric oxide (NO) in the development of intestinal dilation. Brazil strain-infected C57BL/6 wild-type (WT) mice exhibited dilatation of the intestines by 30 days post-infection. Average intestine lumen diameter increased by 72%. Levels of intestinal NO synthase (NOS) isoforms, NOS2 and NOS3, were elevated in infected WT mice. Inflammation and ganglionitis were observed in all infected mice. Intestinal dilation was observed in infected WT, NOS1, NOS2, and NOS3 null mice. This study demonstrates that MRI is a useful tool to monitor intestinal dilation in living mice and that these alterations may begin during acute infection. Furthermore, our data strongly suggests that NO may not be the sole contributor to intestinal dysfunction resulting from this infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Animals
- Base Sequence
- Chagas Disease
- pathology
- DNA Primers
- Fluorescent Antibody Technique
- Intestines
- pathology
- physiopathology
- Magnetic Resonance Imaging
- methods
- Mice
- Nitric Oxide
- physiology
- Nitric Oxide Synthase
- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Trypanosoma cruzi
- isolation & purification
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ny, Lars, 1967
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Li, Hua
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Mukherjee, Shank ...
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Persson, Katarin ...
-
Holmqvist, Bo
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Zhao, Dazhi
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show more...
-
Shtutin, Vitaliy
-
Huang, Huan
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Weiss, Louis M
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Machado, Fabiana ...
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Factor, Stephen ...
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Chan, John
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Tanowitz, Herber ...
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Jelicks, Linda A
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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The American jou ...
- By the university
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University of Gothenburg
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Lund University