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Cerebrospinal fluid...
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Gisslén, Magnus,1962Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
(author)
Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study
- Article/chapterEnglish1998
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LIBRIS-ID:oai:gup.ub.gu.se/83703
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https://gup.ub.gu.se/publication/83703URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.51 log10 copies RNA/ml (p < .01). A significant positive correlation was found between the CSF levels of HIV-I RNA and neopterin (rs = 0.54; p < .001), which increased from 13.6 to 19.6 nmol/L (p < .01). No significant changes in HIV-1 RNA or neopterin levels were found in serum. We suggest that the increase of CSF viral load with time in HIV-1 infection triggers an intrathecal immune activation reflected by increased CSF levels of neopterin. These results are in accordance with the theory that a chronic immune stimulation within the central nervous system (CNS) is involved in the pathogenesis of neurologic HIV-1 disease.
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Hagberg, Lars,1951Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases(Swepub:gu)xhagbl
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Fuchs, Dietmar
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Norkrans, Gunnar,1944Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases(Swepub:gu)xnorgu
(author)
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Svennerholm, Bo,1949Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology(Swepub:gu)xsvebo
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för infektionssjukdomar
(creator_code:org_t)
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In:J Acquir Immune Defic Syndr Hum Retrovirol17:4, s. 291-5
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