Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study

Gisslén, Magnus,1962Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases (author)

HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.51 log10 copies RNA/ml (p < .01). A significant positive correlation was found between the CSF levels of HIV-I RNA and neopterin (rs = 0.54; p < .001), which increased from 13.6 to 19.6 nmol/L (p < .01). No significant changes in HIV-1 RNA or neopterin levels were found in serum. We suggest that the increase of CSF viral load with time in HIV-1 infection triggers an intrathecal immune activation reflected by increased CSF levels of neopterin. These results are in accordance with the theory that a chronic immune stimulation within the central nervous system (CNS) is involved in the pathogenesis of neurologic HIV-1 disease.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adult
CD4 Lymphocyte Count
Cerebrospinal Fluid/*virology
Cohort Studies
Female
Follow-Up Studies
HIV Infections/cerebrospinal fluid/immunology/*virology
HIV-1/genetics/immunology/*physiology
Humans
Longitudinal Studies
Male
Middle Aged
Neopterin/blood/cerebrospinal fluid
Polymerase Chain Reaction
RNA
Viral/blood/*cerebrospinal fluid
*Viral Load

Hagberg, Lars,1951Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases(Swepub:gu)xhagbl (author)
Fuchs, Dietmar (author)
Norkrans, Gunnar,1944Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases(Swepub:gu)xnorgu (author)
Svennerholm, Bo,1949Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology(Swepub:gu)xsvebo (author)
Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för infektionssjukdomar (creator_code:org_t)

By the author/editor: Gisslén, Magnus, ...; Hagberg, Lars, 1 ...; Fuchs, Dietmar; Norkrans, Gunnar ...; Svennerholm, Bo, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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