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Bioimaging TOF-SIMS...
Bioimaging TOF-SIMS: High resolution 3D imaging of single cells.
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- Nygren, Håkan, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
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Hagenhoff, Birgit (author)
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- Malmberg, Per, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
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- Nilsson, Mikael, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
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- Richter, Katrin, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Börner, Katrin, 1979 (author)
- Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Microscopy research and technique. - : Wiley. - 1059-910X .- 1097-0029. ; 70:11, s. 969-74
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Abstract
Subject headings
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- The distribution of phosphocholine ions (m/z 184, m/z 86), sodium ions, and potassium ions in thyroid tumor cells was analyzed by imaging TOF-SIMS. Repeated sputtering with a C(60) (+) source and subsequent analysis with a Bi(3) (+) gun produced a series of 138 images that were stacked to make a 3D display of the chemistry of cells. Phosphocholine was seen in the plasma membrane (m/z 184) and intracellular membranes (m/z 86). The different fragmentation of the phospholipid probably reflects the chemical composition of membranes at these sites. High intensity of secondary ion signals of potassium was seen in membrane-encompassed cellular compartments. The data indicate that potassium ions are compartmentalized in thyroid tumor cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Cell Line
- Tumor
- Humans
- Imaging
- Three-Dimensional
- Ions
- analysis
- Mass Spectrometry
- Phosphorylcholine
- analysis
- Potassium
- analysis
- Sodium
- analysis
- analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nygren, Håkan, 1 ...
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Hagenhoff, Birgi ...
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Malmberg, Per, 1 ...
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Nilsson, Mikael, ...
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Richter, Katrin, ...
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Börner, Katrin, ...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Microscopy resea ...
- By the university
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University of Gothenburg
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Chalmers University of Technology