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Indoor particles af...
Indoor particles affect vascular function in the aged: an air filtration-based intervention study.
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Bräuner, Elvira Vaclavik (author)
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Forchhammer, Lykke (author)
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Moller, Peter (author)
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- Barregård, Lars, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Gunnarsen, Lars (author)
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Afshari, Alireza (author)
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Wåhlin, Peter (author)
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Glasius, Marianne (author)
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Dragsted, Lars Ove (author)
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- Basu, Samar (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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Raaschou-Nielsen, Ole (author)
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Loft, Steffen (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: American journal of respiratory and critical care medicine. - 1535-4970. ; 177:4, s. 419-25
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Abstract
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- RATIONALE: Exposure to particulate matter is associated with risk of cardiovascular events, possibly through endothelial dysfunction, and indoor air may be most important. OBJECTIVES: We investigated effects of controlled exposure to indoor air particles on microvascular function (MVF) as the primary endpoint and biomarkers of inflammation and oxidative stress as secondary endpoints in a healthy elderly population. METHODS: A total of 21 nonsmoking couples participated in a randomized, double-blind, crossover study with two consecutive 48-hour exposures to either particle-filtered or nonfiltered air (2,533-4,058 and 7,718-12,988 particles/cm(3), respectively) in their homes. MEASUREMENTS AND MAIN RESULTS: MVF was assessed noninvasively by measuring digital peripheral artery tone after arm ischemia. Secondary endpoints included hemoglobin, red blood cells, platelet count, coagulation factors, P-selectin, plasma amyloid A, C-reactive protein, fibrinogen, IL-6, tumor necrosis factor-alpha, protein oxidation measured as 2-aminoadipic semialdehyde in plasma, urinary 8-iso-prostaglandin F(2alpha), and blood pressure. Indoor air filtration significantly improved MVF by 8.1% (95% confidence interval, 0.4-16.3%), and the particulate matter (diameter < 2.5 mum) mass of the indoor particles was more important than the total number concentration (10-700 nm) for these effects. MVF was significantly associated with personal exposure to iron, potassium, copper, zinc, arsenic, and lead in the fine fraction. After Bonferroni correction, none of the secondary biomarkers changed significantly. CONCLUSIONS: Reduction of particle exposure by filtration of recirculated indoor air for only 48 hours improved MVF in healthy elderly citizens, suggesting that this may be a feasible way of reducing the risk of cardiovascular disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Administration
- Inhalation
- Age Factors
- Aged
- Air Pollution
- Indoor
- analysis
- prevention & control
- Atherosclerosis
- blood
- etiology
- pathology
- prevention & control
- Confidence Intervals
- Cross-Over Studies
- Double-Blind Method
- Environmental Monitoring
- Female
- Filtration
- methods
- Humans
- Inflammation Mediators
- blood
- Inhalation Exposure
- Intervention Studies
- Male
- Micropore Filters
- Middle Aged
- Nitrogen Dioxide
- analysis
- Oxidative Stress
- Particulate Matter
- toxicity
- Predictive Value of Tests
- Reference Values
- Risk Assessment
- Sensitivity and Specificity
- Sex Factors
- Vasculitis
- blood
- etiology
- prevention & control
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bräuner, Elvira ...
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Forchhammer, Lyk ...
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Moller, Peter
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Barregård, Lars, ...
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Gunnarsen, Lars
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Afshari, Alireza
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show more...
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Wåhlin, Peter
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Glasius, Mariann ...
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Dragsted, Lars O ...
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Basu, Samar
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Raaschou-Nielsen ...
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Loft, Steffen
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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American journal ...
- By the university
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University of Gothenburg
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Uppsala University