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Hypoxia-inducible factor 1 is correlated to serum adiponectin levels and measures of obesity and insulin sensitivity in vivo

Behre, Carl Johan, 1968 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Jernås, Margareta, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Gummesson, Anders, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Carlsson, Lena M S, 1957 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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 (creator_code:org_t)
2009
2009
English.
In: International Congress on Prediabetes and the Metabolic Syndrome.
  • Conference paper (other academic/artistic)
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  • Title: Hypoxia-inducible factor 1 is correlated to serum adiponectin levels and measures of obesity and insulin sensitivity in vivo Background: Hypoxia has been shown to decrease adiponectin in vitro. Adiponectin levels are negatively associated to type 2 diabetes and cardiovascular diseases. Recently, it was shown that Hypoxia-inducible factor 1α (HIF-1) regulates adiponectin expression in murine cardiomyocytes. The present study was performed to examine the association between HIF-1 expression and serum adiponectin levels, measures of adiposity and insulin resistance in humans. Methods: Abdominal subcutaneous adipose tissue biopsies were obtained from 24 subjects diagnosed with and without the metabolic syndrome. HIF-1 gene expression was assessed by individual DNA microarray analyses. Adipose tissue depots were assessed with computerized tomography. Anthropometrics were performed. Circulating levels of insulin, adiponectin, leptin, cholesterol, high-sensitivity C - reactive protein (hs-CRP) and fasting levels of insulin and glucose were measured by standard laboratory procedures. Results: In a univariate analysis, HIF-1 expression levels correlate to BMI (r=0.42, p=0.04), WHR (r=0.55, p=0.0058), total adipose tissue (r=0.46, p=0.022), subcutaneous adipose tissue ( r=0.49, p= 0.016),liver fat (r=0.44, p=0.030), fasting insulin (r=0.46, p=0.023), HOMA-index (r=0.46, p=0.023) and serum adiponectin (r= -0.42, p=0.0418). We observed no statistically significant correlations between HIF-1 gene expression and visceral adipose tissue, systolic blood pressure, serum cholesterol, hs-CRP or serum leptin. HIF-1 gene expression did not differ between the groups. Conclusions: We report that expression of HIF-1 is correlated to serum adiponectin, insulin sensitivity and measures of adiposity. There were no statistical differences in expression of HIF-1 between subjects with or without the metabolic syndrome. In this cross-sectional analysis, no conclusions can be drawn about causality.

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