Temporal and spatial dynamics of brain structure changes during extensive learning.

The current view regarding human long-term memory as an active process of encoding and retrieval includes a highly specific learning-induced functional plasticity in a network of multiple memory systems. Voxel-based morphometry was used to detect possible structural brain changes associated with learning. Magnetic resonance images were obtained at three different time points while medical students learned for their medical examination. During the learning period, the gray matter increased significantly in the posterior and lateral parietal cortex bilaterally. These structural changes did not change significantly toward the third scan during the semester break 3 months after the exam. The posterior hippocampus showed a different pattern over time: the initial increase in gray matter during the learning period was even more pronounced toward the third time point. These results indicate that the acquisition of a great amount of highly abstract information may be related to a particular pattern of structural gray matter changes in particular brain areas.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Adult
Brain
anatomy & histology
physiology
Case-Control Studies
Educational Measurement
Female
Hippocampus
anatomy & histology
physiology
Humans
Learning
physiology
Longitudinal Studies
Magnetic Resonance Imaging
Male
Neuronal Plasticity
Periaqueductal Gray
anatomy & histology
physiology
Students
Medical
Time Factors
posterior parietal cortex
voxel-based morphometry
adult neurogenesis
human hippocampus
memory retrieval
term-memory
network
plasticity
musicians
stress

Gaser, Christian (author)
Kempermann, Gerd (author)
Kuhn, Hans-Georg,1961Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xkuhha (author)
Winkler, Jürgen (author)
Büchel, Christian (author)
May, Arne (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

In:The Journal of neuroscience : the official journal of the Society for Neuroscience26:23, s. 6314-71529-2401

By the author/editor: Draganski, Bogda ...; Gaser, Christian; Kempermann, Gerd; Kuhn, Hans-Georg ...; Winkler, Jürgen; Büchel, Christia ...; show more...; May, Arne; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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