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Air pollution, airw...
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Barraza-Villarreal, Albino
(author)
Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Environmental Health Perspectives,2008
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/87349
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https://gup.ub.gu.se/publication/87349URI
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https://doi.org/10.1289/ehp.10926DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: The biological mechanisms involved in inflammatory response to air pollution are not clearly understood. OBJECTIVE: In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function. METHODS: We studied a cohort of 158 asthmatic and 50 nonasthmatic school-age children, followed an average of 22 weeks. We conducted spirometric tests, measurements of fractional exhaled nitric oxide (Fe(NO)), interleukin-8 (IL-8) in nasal lavage, and pH of exhaled breath condensate every 15 days during follow-up. Data were analyzed using linear mixed-effects models. RESULTS: An increase of 17.5 microg/m(3) in the 8-hr moving average of PM(2.5) levels (interquartile range) was associated with a 1.08-ppb increase in Fe(NO) [95% confidence interval (CI), 1.01-1.16] and a 1.07-pg/mL increase in IL-8 (95% CI 0.98-1.19) in asthmatic children and a 1.16 pg/ml increase in IL-8 (95% CI, 1.00-1.36) in nonasthmatic children. The 5-day accumulated average of exposure to particulate matter <2.5 microm in aerodynamic diamter (PM(2.5)) was significantly inversely associated with forced expiratory volume in 1 sec (FEV(1)) (p=0.048) and forced vital capacity (FVC) (p=0.012) in asthmatic children and with FVC (p=0.021) in nonasthmatic children. Fe(NO) and FEV(1) were inversely associated (p=0.005) in asthmatic children. CONCLUSIONS: Exposure to PM(2.5) resulted in acute airway inflammation and decrease in lung function in both asthmatic and nonasthmatic children.
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Sunyer, Jordi
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Hernandez-Cadena, Leticia
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Escamilla-Nuñez, Maria Consuelo
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Sienra-Monge, Juan Jose
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Ramírez-Aguilar, Matiana
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Cortez-Lugo, Marlene
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Holguin, Fernando
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Diaz-Sánchez, David
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Olin, Anna-Carin,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xolina
(author)
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Romieu, Isabelle
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
(creator_code:org_t)
Related titles
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In:Environmental health perspectives: Environmental Health Perspectives116:6, s. 832-80091-67651552-9924
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