Search: onr:"swepub:oai:gup.ub.gu.se/88037" >
Cytogenetic and spe...
Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours
-
Sjogren, H. (author)
-
Orndal, C. (author)
-
Tingby, O. (author)
-
show more...
-
Meis-Kindblom, J. M. (author)
-
Kindblom, L. G. (author)
-
- Stenman, Göran, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
-
show less...
-
(creator_code:org_t)
- 2004
- 2004
- English.
-
In: International Journal of Oncology. - 1019-6439. ; 24:6, s. 1385-91
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- To date, there have been few studies published on benign and malignant cartilage tumours using high resolution molecular cytogenetic techniques such as spectral karyotyping (SKY). In this study we have used a combination of chromosome banding, SKY and FISH to characterize the chromosomal pattern in 18 benign and malignant cartilage tumours and one small cell osteosarcoma with mesenchymal chondrosarcoma-like features. Clonal structural and/or numerical aberrations were detected in 14 of these tumours. All chondroblastomas and the chondromyxoid fibroma had diploid or near-diploid karyotypes with often relatively simple karyotypes. Although no consistent abnormalities were detected in the chondroblastomas, recurrent breakpoints were found at 2q35, 3q21-23, and 18q21. The chondromyxoid fibroma had an inv(6)(p25q13) as the sole anomaly, suggesting that this is a primary abnormality characteristic of this entity. The karyotypic findings in the chondrosarcomas were, as a rule, more complex than those in the benign tumours. A typical feature was the frequent occurrence of unbalanced rearrangements leading to genomic imbalances with losses and gains of certain chromosomes or chromosome regions. The following breakpoints were recurrent: Xq21, 6p10, 9p13, 20p11 and 22q11-12. Despite the use of high-resolution molecular cytogenetic techniques, we were not able to identify any consistent abnormalities in chondrosarcomas, suggesting that tumour-specific chromosome changes are not likely to be found in this group of tumours.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Bone Neoplasms/*genetics/pathology
- Child
- Chondroblastoma/*genetics/pathology
- Chondrosarcoma/*genetics/pathology
- *Chromosome Aberrations
- Chromosome Banding
- Chromosomes
- Human
- Pair 18/genetics
- Chromosomes
- Human
- Pair 2/genetics
- Chromosomes
- Human
- Pair 3/genetics
- Chromosomes
- Human
- Pair 6/genetics
- Diploidy
- Female
- Gene Rearrangement/genetics
- Humans
- In Situ Hybridization
- Fluorescence
- Inversion
- Chromosome
- Male
- Middle Aged
- Neoplasms/genetics/pathology
- Osteosarcoma/*genetics/pathology
- *Spectral Karyotyping
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database