Opposing effects of adiponectin receptors 1 and 2 on energy metabolism

Bjursell, Mikael, 1977 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology

Ahnmark, Andrea (author)

Bohlooly-Yeganeh, Mohammad, 1966 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology

William-Olsson, Lena (author)

Rhedin, Magdalena (author)

Peng, Xiao-Rong (author)

Ploj, Karolina (author)

Gerdin, Anna-Karin (author)

Arnerup, Gunnel (author)

Elmgren, Anders (author)

Berg, Anna-Lena (author)

Oscarsson, Jan, 1960 (author): Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Wallenberg Laboratory,Institute of Neuroscience and Physiology, Department of Physiology

Lindén, Daniel, 1971 (author): Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory

(creator_code:org_t)

American Diabetes Association, 2007
2007
English.
In: DIABETES. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 56:3, s. 583-593

Related links:: http://diabetes.diab...; show more...; https://gup.ub.gu.se...; https://doi.org/10.2...; show less...

Abstract Subject headings

The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and influences the risk for developing obesity, type 2 diabetes, and cardiovascular disease. Adiponectin binds to two different seven-transmembrane domain receptors termed AdipoR1 and AdipoR2. To study the physiological importance of these receptors, AdipoR1 gene knockout mice (AdipoR1−/−) and AdipoR2 gene knockout mice (AdipoR2−/−) were generated. AdipoR1−/− mice showed increased adiposity associated with decreased glucose tolerance, spontaneous locomotor activity, and energy expenditure. However, AdipoR2−/− mice were lean and resistant to high-fat diet–induced obesity associated with improved glucose tolerance and higher spontaneous locomotor activity and energy expenditure and reduced plasma cholesterol levels. Thus, AdipoR1 and AdipoR2 are clearly involved in energy metabolism but have opposing effects.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

By the author/editor: Bjursell, Mikael ...; Ahnmark, Andrea; Bohlooly-Yeganeh ...; William-Olsson, ...; Rhedin, Magdalen ...; Peng, Xiao-Rong; show more...; Ploj, Karolina; Gerdin, Anna-Kar ...; Arnerup, Gunnel; Elmgren, Anders; Berg, Anna-Lena; Oscarsson, Jan, ...; Lindén, Daniel, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.