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In vitro cellular d...
In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia.
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- Lönnerholm, Gudmar (author)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer),Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
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- Thörn, Ingrid (author)
- Uppsala universitet,Institutionen för genetik och patologi,Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för genetik och patologi,Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden
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- Frost, Britt-Marie (author)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer),Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
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- Abrahamsson, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Qween Silvias Children's Hospital, Gothenburg, Sweden,Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
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- Behrendtz, Mikael (author)
- Östergötlands Läns Landsting,Barn- och ungdomskliniken i Linköping
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- Heldrup, Jesper (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Pediatrics, Lund University Hospital, Lund, Sweden,Univ Lund Hosp, Dept Pediat, S-22185 Lund, Sweden
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- Jacobsson, Stefan, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Clin Chem, Gothenburg, Sweden
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- Li, Aihong (author)
- Umeå universitet,Klinisk kemi,Umea Univ, Dept Biosci, S-90187 Umea, Sweden
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- Olofsson, Tor (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Division of Hematology & Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden,Lund Univ, Dept Lab Med, Div Hematol & Transfus Med, Lund, Sweden
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- Porwit, Anna (author)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden
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- Söderhäll, Stefan (author)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Pediat Oncol, Stockholm, Sweden
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- Larsson, Rolf (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson,Univ Hosp, Pharmacol Sect, Dept Med Sci, Uppsala, Sweden
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- Forestier, Erik (author)
- Umeå universitet,Pediatrik,Umea Univ, Dept Clin Sci, S-90187 Umea, Sweden
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(creator_code:org_t)
- Oxford : Elsevier BV, 2009
- 2009
- English.
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In: Leukemia research. - Oxford : Elsevier BV. - 0145-2126 .- 1873-5835. ; 33:1, s. 46-53
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Abstract
Subject headings
Close
- Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p<0.001) and doxorubicin (p=0.017), drugs administered during induction therapy. In patients with t(12;21) (n=20), in vitro sensitivity to doxorubicin was an independent factor for MRD <0.1% (p=0.031; R(2)=0.66). Thus, data show that in vitro drug sensitivity at diagnosis is correlated to cell kill during induction therapy as measured by MRD day 29.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
- therapeutic use
- Child
- Child
- Preschool
- Doxorubicin
- administration & dosage
- Humans
- Infant
- Neoplasm
- Residual
- diagnosis
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- drug therapy
- pathology
- Prednisolone
- administration & dosage
- 21)
- t(12
- MRD
- In vitro drug resistance
- Acute lymphoblastic leukemia
- Childhood
- Acute lymphoblastic leukemia
- Clinical chemistry
- Clinical Chemistry
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lönnerholm, Gudm ...
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Thörn, Ingrid
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Sundström, Chris ...
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Frost, Britt-Mar ...
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Abrahamsson, Jon ...
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Behrendtz, Mikae ...
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show more...
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Heldrup, Jesper
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Jacobsson, Stefa ...
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Li, Aihong
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Olofsson, Tor
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Porwit, Anna
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Söderhäll, Stefa ...
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Larsson, Rolf
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Forestier, Erik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Leukemia researc ...
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Leukemia Researc ...
- By the university
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University of Gothenburg
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Lund University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Linköping University