Search: onr:"swepub:oai:gup.ub.gu.se/89421" >
In vitro cellular d...
-
Lönnerholm, GudmarUppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer),Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
(author)
In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/89421
-
https://gup.ub.gu.se/publication/89421URI
-
https://doi.org/10.1016/j.leukres.2008.06.012DOI
-
https://lup.lub.lu.se/record/1313732URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-24691URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-87879URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:118010148URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16246URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p<0.001) and doxorubicin (p=0.017), drugs administered during induction therapy. In patients with t(12;21) (n=20), in vitro sensitivity to doxorubicin was an independent factor for MRD <0.1% (p=0.031; R(2)=0.66). Thus, data show that in vitro drug sensitivity at diagnosis is correlated to cell kill during induction therapy as measured by MRD day 29.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Thörn, IngridUppsala universitet,Institutionen för genetik och patologi,Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden(Swepub:uu)intho172
(author)
-
Sundström, ChristerUppsala universitet,Institutionen för genetik och patologi,Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden(Swepub:uu)chrisund
(author)
-
Frost, Britt-MarieUppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer),Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden(Swepub:uu)brittfo
(author)
-
Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Qween Silvias Children's Hospital, Gothenburg, Sweden,Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden(Swepub:gu)xabrjo
(author)
-
Behrendtz, MikaelÖstergötlands Läns Landsting,Barn- och ungdomskliniken i Linköping
(author)
-
Heldrup, JesperLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Pediatrics, Lund University Hospital, Lund, Sweden,Univ Lund Hosp, Dept Pediat, S-22185 Lund, Sweden(Swepub:lu)pedi-jhe
(author)
-
Jacobsson, Stefan,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Clin Chem, Gothenburg, Sweden(Swepub:gu)xjacst
(author)
-
Li, AihongUmeå universitet,Klinisk kemi,Umea Univ, Dept Biosci, S-90187 Umea, Sweden(Swepub:umu)liai0001
(author)
-
Olofsson, TorLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Division of Hematology & Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden,Lund Univ, Dept Lab Med, Div Hematol & Transfus Med, Lund, Sweden(Swepub:lu)efor-tol
(author)
-
Porwit, AnnaKarolinska Institutet,Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden
(author)
-
Söderhäll, StefanKarolinska Institutet,Karolinska Univ Hosp, Dept Pediat Oncol, Stockholm, Sweden
(author)
-
Larsson, RolfUppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson,Univ Hosp, Pharmacol Sect, Dept Med Sci, Uppsala, Sweden(Swepub:uu)rolflars
(author)
-
Forestier, ErikUmeå universitet,Pediatrik,Umea Univ, Dept Clin Sci, S-90187 Umea, Sweden(Swepub:umu)erfo0007
(author)
-
Uppsala universitetPediatrik
(creator_code:org_t)
Related titles
-
In:Leukemia researchOxford : Elsevier BV33:1, s. 46-530145-21261873-5835
-
In:Leukemia Research: A Forum for Studies on Leukemia and Normal HemopoiesisOxford : Elsevier BV33:1, s. 46-531873-5835
Internet link
Find in a library
To the university's database
- By the author/editor
-
Lönnerholm, Gudm ...
-
Thörn, Ingrid
-
Sundström, Chris ...
-
Frost, Britt-Mar ...
-
Abrahamsson, Jon ...
-
Behrendtz, Mikae ...
-
show more...
-
Heldrup, Jesper
-
Jacobsson, Stefa ...
-
Li, Aihong
-
Olofsson, Tor
-
Porwit, Anna
-
Söderhäll, Stefa ...
-
Larsson, Rolf
-
Forestier, Erik
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
- Articles in the publication
-
Leukemia researc ...
-
Leukemia Researc ...
- By the university
-
University of Gothenburg
-
Lund University
-
Umeå University
-
Uppsala University
-
Karolinska Institutet
-
Linköping University