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The relative import...
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
(author)
The relative importance of endocrine versus autocrine/paracrine insulin-like growth factor-I in the regulation of body growth.
- Article/chapterEnglish2000
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LIBRIS-ID:oai:gup.ub.gu.se/91422
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https://gup.ub.gu.se/publication/91422URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Body growth is regulated by growth hormone (GH) and insulin-like growth factor-I (IGF-I). The classical somatomedin hypothesis of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have recently abolished IGF-I production in the livers of mice by using the Cre/loxP recombination system. These mice displayed a more than 75% reduction in serum IGF-I associated with increased serum levels of GH. In contrast, they demonstrated a normal postnatal growth, indicating that extrahepatic, autocrine/paracrine-acting IGF-I is the main determinant of postnatal growth. Thus, the "classical" somatomedin hypothesis needs revision. We propose the "dual somatomedin hypothesis" according to which: (1) autocrine/paracrine IGF-I is the main determinant of postnatal body growth and (2) liver-derived, endocrine-acting, IGF-I exerts negative feedback on GH secretion and possibly also exerts other effects on carbohydrate and lipid metabolism.
Subject headings and genre
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Animals
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Autocrine Communication
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physiology
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Endocrine Glands
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physiology
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Growth
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physiology
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Growth Hormone
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physiology
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Humans
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Insulin-Like Growth Factor I
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physiology
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Paracrine Communication
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physiology
Added entries (persons, corporate bodies, meetings, titles ...)
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Sjögren, Klara,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsjokl
(author)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xjanjo
(author)
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Isaksson, Olle,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xisaol
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin
(creator_code:org_t)
Related titles
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In:Pediatric nephrology (Berlin, Germany)14:7, s. 541-30931-041X
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