onr:"swepub:oai:gup.ub.gu.se/91422"
Search: onr:"swepub:oai:gup.ub.gu.se/91422" > The relative import...
- 1 of 1
- Previous record
- Next record
- To hitlist
The relative importance of endocrine versus autocrine/paracrine insulin-like growth factor-I in the regulation of body growth.
-
- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
-
- Sjögren, Klara, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
-
- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
- show more...
- show less...
- (creator_code:org_t)
- 2000
- 2000
- English.
- In: Pediatric nephrology (Berlin, Germany). - 0931-041X. ; 14:7, s. 541-3
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Body growth is regulated by growth hormone (GH) and insulin-like growth factor-I (IGF-I). The classical somatomedin hypothesis of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have recently abolished IGF-I production in the livers of mice by using the Cre/loxP recombination system. These mice displayed a more than 75% reduction in serum IGF-I associated with increased serum levels of GH. In contrast, they demonstrated a normal postnatal growth, indicating that extrahepatic, autocrine/paracrine-acting IGF-I is the main determinant of postnatal growth. Thus, the "classical" somatomedin hypothesis needs revision. We propose the "dual somatomedin hypothesis" according to which: (1) autocrine/paracrine IGF-I is the main determinant of postnatal body growth and (2) liver-derived, endocrine-acting, IGF-I exerts negative feedback on GH secretion and possibly also exerts other effects on carbohydrate and lipid metabolism.
Keyword
- Animals
- Autocrine Communication
- physiology
- Endocrine Glands
- physiology
- Growth
- physiology
- Growth Hormone
- physiology
- Humans
- Insulin-Like Growth Factor I
- physiology
- Paracrine Communication
- physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Pediatric nephrology (Berlin, Germany) (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ohlsson, Claes, ...
- Sjögren, Klara, ...
- Jansson, John-Ol ...
- Isaksson, Olle, ...
- Articles in the publication
- Pediatric nephro ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
