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Estrogen receptor s...
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice.
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- Vidal, Olle (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Lindberg, Marie K, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Hollberg, K (author)
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Baylink, D J (author)
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- Andersson, G (author)
- Karolinska Institutet
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Lubahn, D B (author)
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Mohan, Subburaman (author)
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Gustafsson, J A (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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(creator_code:org_t)
- Proceedings of the National Academy of Sciences, 2000
- 2000
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 97:10, s. 5474-9
- Related links:
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http://www.pnas.org/...
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Abstract
Subject headings
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- Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERalpha-knockout (ERKO), ERbeta-knockout (BERKO), and double ERalpha/beta-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERalpha, but not ERbeta, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.
Keyword
- Animals
- Bone Density
- Bone Development
- genetics
- physiology
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Female
- Genotype
- Growth Plate
- growth & development
- Heterozygote
- Insulin-Like Growth Factor I
- metabolism
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Receptors
- Estrogen
- deficiency
- genetics
- physiology
- Sex Characteristics
- Tibia
- growth & development
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vidal, Olle
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Lindberg, Marie ...
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Hollberg, K
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Baylink, D J
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Andersson, G
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Lubahn, D B
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show more...
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Mohan, Subburama ...
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Gustafsson, J A
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Ohlsson, Claes, ...
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show less...
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Karolinska Institutet