Search: onr:"swepub:oai:gup.ub.gu.se/91431" >
Disproportional ske...
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Sjögren, Klara,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
(author)
Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice.
- Article/chapterEnglish2000
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/91431
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https://gup.ub.gu.se/publication/91431URI
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https://doi.org/10.1006/bbrc.1999.1986DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Growth hormone (GH) is important for skeletal growth as well as for a normal bone metabolism in adults. The skeletal growth and adult bone metabolism was studied in mice with an inactivated growth hormone receptor (GHR) gene. The lengths of femur, tibia, and crown-rump were, as expected, decreased in GHR-/- mice. Unexpectedly, GHR-/- mice displayed disproportional skeletal growth reflected by decreased femur/crown-rump and femur/tibia ratios. GHR-/- mice demonstrated decreased width of the growth plates in the long bones and disturbed ossification of the proximal tibial epiphysis. Furthermore, the area bone mineral density (BMD) as well as the bone mineral content (BMC)/body weight were markedly decreased in GHR-/- mice. The decrease in BMC in GHR-/- mice was not due to decreased trabecular volumetric BMD but to a decreased cross-sectional cortical bone area In conclusion, GHR-/- mice demonstrate disproportional skeletal growth and markedly decreased bone mineral content.
Subject headings and genre
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Animals
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Base Sequence
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Biological Markers
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blood
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Bone Density
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genetics
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physiology
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Bone Development
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genetics
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physiology
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DNA Primers
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genetics
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Femur
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growth & development
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Growth Hormone
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physiology
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Insulin-Like Growth Factor I
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genetics
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metabolism
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Male
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Mice
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Mice
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Knockout
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Organ Size
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Organ Specificity
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RNA
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Messenger
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genetics
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metabolism
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Receptors
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Somatotropin
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deficiency
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genetics
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Tibia
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growth & development
Added entries (persons, corporate bodies, meetings, titles ...)
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Bohlooly-Yeganeh, Mohammad,1966Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xbohmo
(author)
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Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xolsbo
(author)
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Coschigano, Karen T
(author)
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Törnell, Jan,1960Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xtornj
(author)
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Mohan, Subburaman
(author)
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Isaksson, Olle,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xisaol
(author)
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Baumann, G
(author)
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Kopchick, John J
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin
(creator_code:org_t)
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In:Biochemical and biophysical research communications: Elsevier BV267:2, s. 603-80006-291X
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