onr:"swepub:oai:gup.ub.gu.se/91432"
Search: onr:"swepub:oai:gup.ub.gu.se/91432" > Disproportional bod...
- 1 of 1
- Previous record
- Next record
- To hitlist
Disproportional body growth in female estrogen receptor-alpha-inactivated mice.
- Vidal, Olle (author)
-
- Lindberg, Marie K, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Sävendahl, Lars (author)
- Karolinska Institutet
- show more...
- Lubahn, D B (author)
- show less...
- (creator_code:org_t)
- Elsevier BV, 1999
- 1999
- English.
- In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 265:2, s. 569-71
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERalpha (ERalpha-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERalpha-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERalpha-/- mice.
Keyword
- Animals
- Base Sequence
- Body Weight
- genetics
- physiology
- Bone Development
- genetics
- physiology
- DNA Primers
- genetics
- Estrogen Receptor alpha
- Female
- Growth
- genetics
- physiology
- Growth Plate
- growth & development
- Humans
- Insulin-Like Growth Factor I
- metabolism
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Organ Size
- genetics
- physiology
- Phenotype
- Receptors
- Estrogen
- genetics
- physiology
- Species Specificity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Biochemical and biophysical research communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Vidal, Olle
- Lindberg, Marie ...
- Sävendahl, Lars
- Lubahn, D B
- Ritzen, E M
- Gustafsson, J A
- show more...
- Ohlsson, Claes, ...
- show less...
- Articles in the publication
- Biochemical and ...
- By the university
- University of Gothenburg
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
