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- Nilsson, Anders,1958Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics (author)
Hormonal regulation of longitudinal bone growth.
- Article/chapterEnglish1994
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- 1994
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- LIBRIS-ID:oai:gup.ub.gu.se/91639
- https://gup.ub.gu.se/publication/91639URI
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- Language:English
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Notes
- The regulation of postnatal somatic growth is complex. Genetic, nutritional factors and hormones exert regulatory functions. Hormones that have an established role in the regulation include growth hormone (GH), thyroid hormone and sex steroids. GH promotes mainly the growth of the long bones in terms of final height, while the action of the sex steroids and thyroid hormone is less well known. Longitudinal bone growth is the result of chondrocyte proliferation and subsequent endochondral ossification in the epiphyseal growth-plates. The growth-plate is a cartilaginous template that is located between the epiphysis and the metaphysis of the long bones. GH and insulin-like growth factor-I (IGF-I) have different target cells in the epiphyseal growth-plate. GH stimulates the slowly dividing prechondrocytes in the germinative cell layer while IGF-I promotes the clonal expansion in the proliferative cell layer of a GH primed cell. Thyroid hormone blocks the clonal expansion and stimulates chondrocyte maturation. IGF-I mRNA is primarily regulated by GH, and IGF-I is produced in several tissues such as the liver, muscle, fat and epiphyseal growth plates. However, IGF-I mRNA is also increased during compensatory growth of heart and kidneys and by estrogen in the Fallopian tube in the rat. Nutrition, i.e. energy from fat and carbohydrates and proteins, also influences the final height, but the cellular mechanism of action is not known. The aim of this article is to review hormonal action on longitudinal bone growth.
Subject headings and genre
- Animals
- Bone Development
- physiology
- Cell Division
- Epiphyses
- cytology
- metabolism
- physiology
- Gonadal Steroid Hormones
- physiology
- Growth Hormone
- physiology
- Growth Plate
- physiology
- Humans
- Insulin-Like Growth Factor I
- genetics
- metabolism
- Nutritional Physiological Phenomena
- Osteocytes
- cytology
- metabolism
- physiology
- RNA
- Messenger
- Thyroid Hormones
- physiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (author)
- Isaksson, Olle,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xisaol (author)
- Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xlandy (author)
- Isgaard, Jörgen,1959Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xisgjo (author)
- Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi (creator_code:org_t)
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- In:European journal of clinical nutrition48 Suppl 10954-3007
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