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Hypothalamic gene e...
Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents.
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- Egecioglu, Emil, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Stenström, Björn (author)
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Pinnock, Scarlett B (author)
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Tung, Loraine Y C (author)
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- de la Cour, Charlotta (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Lindqvist, Andreas (author)
- Lund University,Lunds universitet,Aptitkontroll,Forskargrupper vid Lunds universitet,Appetite Regulation,Lund University Research Groups
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- Håkanson, Rolf (author)
- Lund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups
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Syversen, Unni (author)
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Chen, Duan (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Regulatory peptides. - : Elsevier BV. - 0167-0115 .- 1873-1686. ; 146:1-3, s. 176-82
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Abstract
Subject headings
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- We investigated whether ghrelin depletion (by gastrectomy surgery) and/or treatment/replacement with the gastric hormone ghrelin alters the expression of key hypothalamic genes involved in energy balance, in a manner consistent with ghrelin's pro-obesity effects. At 2 weeks after surgery mice were treated with ghrelin (12 nmol/mouse/day, sc) or vehicle for 8 weeks. Gastrectomy had little effect on the expression of these genes, with the exception of NPY mRNA in the arcuate nucleus that was increased. Ghrelin treatment (to gastrectomized and sham mice) increased the mRNA expression of orexigenic peptides NPY and AgRP while decreasing mRNA expression of the anorexigenic peptide POMC. Two weeks gavage treatment with the ghrelin mimetic, MK-0677, to rats increased NPY and POMC mRNA in the arcuate nucleus and MCH mRNA in the lateral hypothalamus. Thus, while predicted pro-obesity ghrelin signalling pathways were activated by ghrelin and ghrelin mimetics, these were largely unaffected by gastrectomy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Agouti-Related Protein
- genetics
- metabolism
- Animals
- Female
- Gastrectomy
- Gene Expression Regulation
- Ghrelin
- pharmacology
- Hypothalamus
- metabolism
- Mice
- Neuropeptide Y
- genetics
- metabolism
- Pro-Opiomelanocortin
- genetics
- metabolism
- RNA
- Messenger
- biosynthesis
- Rats
- Stomach
- surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Egecioglu, Emil, ...
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Stenström, Björn
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Pinnock, Scarlet ...
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Tung, Loraine Y ...
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de la Cour, Char ...
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Lindqvist, Andre ...
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show more...
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Håkanson, Rolf
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Syversen, Unni
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Chen, Duan
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Dickson, Suzanne ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Regulatory pepti ...
- By the university
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University of Gothenburg
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Lund University