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Joint analysis of i...
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-07-08
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Informa UK Limited,2009
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/93821
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https://gup.ub.gu.se/publication/93821URI
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https://doi.org/10.1080/07853890802337037DOI
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https://lup.lub.lu.se/record/1372595URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. AIMS: This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). METHODS: Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. RESULTS: The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and BMI or interleukin-6 levels, except in some subgroups. CONCLUSIONS: Our data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
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Illig, Thomas
(author)
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Herder, Christian
(author)
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Gieger, Christian
(author)
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Grallert, Harald
(author)
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Vollmert, Caren
(author)
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Rathmann, Wolfgang
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Hamid, Yasmin H
(author)
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Pedersen, Oluf
(author)
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Hansen, Torben
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Thorand, Barbara
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Meisinger, Christa
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Doring, Angela
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Klopp, Norman
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Gohlke, Henning
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Lieb, Wolfgang
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Hengstenberg, Christian
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Lyssenko, Valeriya
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
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Ireland, Helen
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Stephens, Jeffrey W
(author)
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Wernstedt Asterholm, Ingrid,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xwerni
(author)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanjo
(author)
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Boeing, Heiner
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Mohlig, Matthias
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Stringham, Heather M
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Boehnke, Michael
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Tuomilehto, Jaakko
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Fernandez-Real, Jose-Manuel
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Lopez-Bermejo, Abel
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Gallart, Luis
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Vendrell, Joan
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Humphries, Steve E
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Kronenberg, Florian
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Wichmann, H-Erich
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Heid, Iris M
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Annals of medicine: Informa UK Limited41:2, s. 128-381365-20600785-3890
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Illig, Thomas
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Herder, Christia ...
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Grallert, Harald
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Vollmert, Caren
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Rathmann, Wolfga ...
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Hamid, Yasmin H
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Pedersen, Oluf
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Hansen, Torben
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Thorand, Barbara
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Meisinger, Chris ...
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Doring, Angela
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Klopp, Norman
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Gohlke, Henning
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Lieb, Wolfgang
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Hengstenberg, Ch ...
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Lyssenko, Valeri ...
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Groop, Leif
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Ireland, Helen
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Stephens, Jeffre ...
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Wernstedt Asterh ...
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Jansson, John-Ol ...
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Boeing, Heiner
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Mohlig, Matthias
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Stringham, Heath ...
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Boehnke, Michael
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Tuomilehto, Jaak ...
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Fernandez-Real, ...
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Gallart, Luis
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