onr:"swepub:oai:gup.ub.gu.se/95488"
Search: onr:"swepub:oai:gup.ub.gu.se/95488" > Atherosclerotic mic...
- 1 of 1
- Previous record
- Next record
- To hitlist
Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets.
- Lohmann, C (author)
- Schäfer, N (author)
- von Lukowicz, Tobias (author)
- show more...
- Sokrates Stein, MA (author)
- Rütti, S (author)
- Wahli, W (author)
- Donath, MY (author)
- Lüscher, TF (author)
- Matter, CM (author)
- show less...
- (creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
- In: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 207:2, s. 360-367
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- OBJECTIVE: Atherosclerosis is a chronic inflammatory disease of major conduit arteries. Similarly, obesity and type 2 diabetes mellitus are associated with accumulation of macrophages in visceral white adipose tissue and pancreatic islets. Our goal was to characterize systemic inflammation in atherosclerosis with hypercholesterolemia, but without obesity. METHODS AND RESULTS: We compared 22-week-old apolipoprotein E knockout (ApoE(-/-)) with wild-type mice kept for 14 weeks on a high cholesterol (1.25%) diet (CD, n=8) and 8-week-old ApoE(-/-) with wild-type mice kept on a normal diet (ND, n=8). Hypercholesterolemic, atherosclerotic ApoE(-/-) mice on CD exhibited increased macrophages and T-cells in plaques and periadventitial adipose tissue that revealed elevated expression of MIP-1alpha, IL-1beta, IL-1 receptor, and IL-6. Mesenteric adipose tissue and pancreatic islets in ApoE(-/-) mice showed increased macrophages. Expression of IL-1beta was enhanced in mesenteric adipose tissue of ApoE(-/-) mice on CD. Furthermore, these mice exhibited steatohepatitis with macrophage and T-cell infiltrations as well as increased MIP-1alpha and IL-1 receptor expression. Blood glucose, insulin and total body weight did not differ between the groups. CONCLUSIONS: In hypercholesterolemic lean ApoE(-/-) mice, inflammation extends beyond atherosclerotic plaques to the periadventitial and visceral adipose tissue, liver, and pancreatic islets without affecting glucose homeostasis.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Atherosclerosis (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lohmann, C
- Schäfer, N
- von Lukowicz, To ...
- Sokrates Stein, ...
- Borén, Jan, 1963
- Rütti, S
- show more...
- Wahli, W
- Donath, MY
- Lüscher, TF
- Matter, CM
- show less...
- Articles in the publication
- Atherosclerosis
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
