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FOXC2 controls Ang-...
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
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- Xue, Yuan (author)
- Karolinska Institutet
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- Cao, Renhai (author)
- Karolinska Institutet
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- Nilsson, Daniel, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Chen, Shaohua (author)
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- Westergren, Rickard, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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- Hedlund, Eva-Maria (author)
- Karolinska Institutet
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- Martijn, Cecile (author)
- Biovitrum AB, Stockholm, Sweden
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Rondahl, Lena (author)
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Krauli, Per (author)
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Walum, Erik (author)
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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- Cao, Yihai (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-07-22
- 2008
- English.
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In: Proceedings of The National Academy of Sciences of The United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 105:29, s. 10167-10172
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Abstract
Subject headings
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- Adipogenesis is spatiotemporally coupled to angiogenesis throughout adult life, and the interplay between these two processes is communicated by multiple factors. Here we show that in a transgenic mouse model, increased expression of forkhead box C2 (FOXC2) in the adipose tissue affects angiogenesis, vascular patterning, and functions. White and brown adipose tissues contain a considerably high density of microvessels appearing as vascular plexuses, which show redistribution of vascular smooth muscle cells and pericytes. Dysfunction of these primitive vessels is reflected by impairment of skin wound healing. We further provide a mechanistic insight of the vascular phenotype by showing that FOXC2 controls Ang-2 expression by direct activation of its promoter in adipocytes. Remarkably, an Ang-2-specific antagonist almost completely reverses this vascular phenotype. Thus, the FOXC2–Ang-2 signaling system is crucial for controlling adipose vascular function, which is part of an adaptation to increased adipose tissue metabolism.
Subject headings
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Tvärvetenskapliga studier inom samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Social Sciences Interdisciplinary (hsv//eng)
Keyword
- endothelial growth-factor
- lymphedema-distichiasis syndrome
- messenger-rna expression
- factor gene-expression
- in-vitro
- brown adipocytes
- obesity
- cells
- angiopoietin-2
- leptin
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Xue, Yuan
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Cao, Renhai
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Nilsson, Daniel, ...
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Chen, Shaohua
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Westergren, Rick ...
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Hedlund, Eva-Mar ...
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show more...
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Martijn, Cecile
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Rondahl, Lena
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Krauli, Per
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Walum, Erik
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Enerbäck, Sven, ...
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Cao, Yihai
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Other Social Sci ...
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and Social Sciences ...
- Articles in the publication
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Proceedings of T ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet