Health-related quality of life in secondary progressive multiple sclerosis.

Common disability scales in multiple sclerosis (MS) are often weighted towards physical disability. Non-motor symptoms such as depression, fatigue and pain substantially influence wellbeing in MS. Health-related quality of life (HRQoL) measures the broader impact of MS and might indicate less obvious disease burdens. We analysed HRQoL, using the Nottingham Health Profile Part I (NHP-I), among 345 secondary progressive MS (SPMS) patients participating in a randomized trial of interferon-beta1a (IFN-beta1a), 22 mug subcutaneously weekly, or matching placebo. The results did not reveal any beneficial effect of IFN-beta1a in any outcome measure. NHP-I sub- and sum scores were compared for 217 population controls and correlated with demographic and clinical disease variables. SPMS patients had lower NHP-I sum and all subscores than the controls. Patients experiencing disease progression reported worse NHP-I sum scores. Increased fatigue, Expanded Disability Status Scale (EDSS) and Arm Index scores were independently associated with reduction in several NHP-I subscores. SPMS patients had significantly lower HRQoL than controls and physical disability (EDSS and Arm Index), disease progression and fatigue strongly influenced this. MS.

Naess, H (author)
Aarseth, J H (author)
Andersen, Oluf,1941Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xandeo (author)
Elovaara, I (author)
Farkkila, M (author)
Hansen, H J (author)
Mellgren, S I (author)
Sandberg-Wollheim, M (author)
Sorensen, P S (author)
Myhr, K M (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

In:Multiple sclerosis (Houndmills, Basingstoke, England): SAGE Publications13:3, s. 386-921352-45851477-0970

By the author/editor: Beiske, A G; Naess, H; Aarseth, J H; Andersen, Oluf, ...; Elovaara, I; Farkkila, M; show more...; Hansen, H J; Mellgren, S I; Sandberg-Wollhei ...; Sorensen, P S; Myhr, K M; show less...

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