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Health-related qual...
Health-related quality of life in secondary progressive multiple sclerosis.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007-01-29
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SAGE Publications,2007
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/97542
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https://gup.ub.gu.se/publication/97542URI
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https://doi.org/10.1177/13524585070130030101DOI
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https://doi.org/10.1177/1352458506069247DOI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Common disability scales in multiple sclerosis (MS) are often weighted towards physical disability. Non-motor symptoms such as depression, fatigue and pain substantially influence wellbeing in MS. Health-related quality of life (HRQoL) measures the broader impact of MS and might indicate less obvious disease burdens. We analysed HRQoL, using the Nottingham Health Profile Part I (NHP-I), among 345 secondary progressive MS (SPMS) patients participating in a randomized trial of interferon-beta1a (IFN-beta1a), 22 mug subcutaneously weekly, or matching placebo. The results did not reveal any beneficial effect of IFN-beta1a in any outcome measure. NHP-I sub- and sum scores were compared for 217 population controls and correlated with demographic and clinical disease variables. SPMS patients had lower NHP-I sum and all subscores than the controls. Patients experiencing disease progression reported worse NHP-I sum scores. Increased fatigue, Expanded Disability Status Scale (EDSS) and Arm Index scores were independently associated with reduction in several NHP-I subscores. SPMS patients had significantly lower HRQoL than controls and physical disability (EDSS and Arm Index), disease progression and fatigue strongly influenced this. MS.
Subject headings and genre
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Disease Progression
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Emotions
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Fatigue
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Female
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Health Status
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Humans
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Male
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Mobility Limitation
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Multiple Sclerosis
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Chronic Progressive
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physiopathology
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psychology
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Pain
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Quality of Life
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Sleep
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Social Isolation
Added entries (persons, corporate bodies, meetings, titles ...)
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Naess, H
(author)
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Aarseth, J H
(author)
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Andersen, Oluf,1941Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xandeo
(author)
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Elovaara, I
(author)
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Farkkila, M
(author)
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Hansen, H J
(author)
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Mellgren, S I
(author)
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Sandberg-Wollheim, M
(author)
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Sorensen, P S
(author)
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Myhr, K M
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
(creator_code:org_t)
Related titles
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In:Multiple sclerosis (Houndmills, Basingstoke, England): SAGE Publications13:3, s. 386-921352-45851477-0970
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Beiske, A G
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Naess, H
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Aarseth, J H
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Andersen, Oluf, ...
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Elovaara, I
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Farkkila, M
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Hansen, H J
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Mellgren, S I
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Sandberg-Wollhei ...
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Sorensen, P S
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Myhr, K M
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- Articles in the publication
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Multiple scleros ...
- By the university
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University of Gothenburg