Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease.

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Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease.

Brys, Miroslaw (author)

Glodzik, Lidia (author)

Mosconi, Lisa (author)

Switalski, Remigiusz (author)

De Santi, Susan (author)

Pirraglia, Elizabeth (author)

Rich, Kenneth (author)

Kim, Byeong C (author)

Mehta, Pankaj (author)

Zinkowski, Ray (author)

Pratico, Domenico (author)

Wallin, Anders, 1950 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Zetterberg, Henrik, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Tsui, Wai H (author)

Rusinek, Henry (author)

Blennow, Kaj, 1958 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

de Leon, Mony J (author)

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(creator_code:org_t)

2009
2009
English.
In: Journal of Alzheimer's disease : JAD. - 1387-2877. ; 16:2, s. 351-62

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Little is known of combined utility of magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers for prediction of Alzheimer's disease (AD) and longitudinal data is scarce. We examined these biomarkers at baseline and longitudinally in incipient AD. Forty-five subjects [21 controls (NL-NL), 16 stable MCI (MCI-MCI), 8 MCI who declined to AD (MCI-AD)] received MRI and lumbar puncture at baseline and after 2 years. CSF measures included total and phosphorylated tau (T-tau, P-tau(231)), amyloid-beta (Abeta(42)/Abeta(40)) and isoprostane. Voxel-based morphometry identified gray matter concentration (GMC) differences best distinguishing study groups and individual GMC values were calculated. Rate of medial temporal lobe (MTL) atrophy was examined using regional boundary shift (rBS) method. At baseline, for MRI, MCI-AD showed reduced GMC-MTL, and for CSF higher CSF T-tau, P-tau(231), IP and lower Abeta(42)/Abeta(40) as compared with MCI-MCI or NL-NL. Longitudinally, rBS-MTL atrophy was higher in MCI-AD than in either MCI-MCI or NL-NL, particularly in the left hemisphere. CSF data showed longitudinally greater increases of isoprostane in MCI-AD as compared with NL-NL. Combining baseline CSF-P-tau(231) and GMC-MTL significantly increased overall prediction of AD from 74% to 84% (p(step)<0.05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Aged
Alzheimer Disease
cerebrospinal fluid
complications
genetics
pathology
Amyloid beta-Protein
cerebrospinal fluid
Apolipoprotein E4
genetics
Area Under Curve
Cognition Disorders
cerebrospinal fluid
complications
diagnosis
genetics
Female
Functional Laterality
Gas Chromatography-Mass Spectrometry
Humans
Image Processing
Computer-Assisted
Isoprostanes
cerebrospinal fluid
Longitudinal Studies
Magnetic Resonance Imaging
methods
Male
Middle Aged
Peptide Fragments
cerebrospinal fluid
Sensitivity and Specificity
tau Proteins
cerebrospinal fluid

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Brys, Miroslaw; Glodzik, Lidia; Mosconi, Lisa; Switalski, Remig ...; De Santi, Susan; Pirraglia, Eliza ...; show more...; Rich, Kenneth; Kim, Byeong C; Mehta, Pankaj; Zinkowski, Ray; Pratico, Domenic ...; Wallin, Anders, ...; Zetterberg, Henr ...; Tsui, Wai H; Rusinek, Henry; Blennow, Kaj, 19 ...; de Leon, Mony J; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Journal of Alzhe ...

By the university: University of Gothenburg

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