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Rapid progression f...
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.
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- Blom, Elin S. (author)
- Uppsala universitet,Geriatrik
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fukumoto, Hiroaki (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hyman, Bradley T (author)
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Irizarry, Michael C (author)
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- Wahlund, Lars-Olof (author)
- Karolinska Institutet
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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(creator_code:org_t)
- 2009-05-07
- 2009
- English.
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In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 27:5, s. 458-64
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Abstract
Subject headings
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- BACKGROUND/AIMS: Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on the rate of disease progression. METHODS: Using ELISA, we measured the CSF biomarkers in 47 AD patients, 58 patients with MCI and 35 healthy control subjects. Twenty-eight MCI patients revisited the clinic and half of them progressed to AD during a period of 3-12 years. RESULTS: The expected changes in CSF total (T)-tau, phosphorylated (P)-tau and Abeta42 levels were found in AD, confirming the diagnostic value of these biomarkers. We were also able to corroborate an increased risk for progression from MCI to AD with elevated CSF T-tau and P-tau and with the presence of the APOE epsilon4/epsilon4 genotype, but not with decreased Abeta42. Finally, for the first time we demonstrated that MCI subjects with high CSF T-tau or P-tau and APOE epsilon4 homozygosity progressed faster from MCI to AD. CONCLUSIONS: CSF T-tau and P-tau as well as the APOE epsilon4/epsilon4 genotype are robust predictors of AD and are also associated with a more rapid progression from MCI to AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Aged
- Alzheimer Disease
- psychology
- Amyloid beta-Protein
- cerebrospinal fluid
- genetics
- Apolipoprotein E4
- cerebrospinal fluid
- genetics
- Biological Markers
- Cognition Disorders
- psychology
- Disease Progression
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Peptide Fragments
- cerebrospinal fluid
- genetics
- tau Proteins
- cerebrospinal fluid
- Alzheimer’s disease
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Blom, Elin S.
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Giedraitis, Vilm ...
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Zetterberg, Henr ...
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Fukumoto, Hiroak ...
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Blennow, Kaj, 19 ...
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Hyman, Bradley T
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show more...
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Irizarry, Michae ...
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Wahlund, Lars-Ol ...
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Lannfelt, Lars
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Ingelsson, Marti ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Dementia and ger ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet