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Synaptic retrogenes...
Synaptic retrogenesis and amyloid-beta in Alzheimer's disease.
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Wasling, Pontus (author)
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Daborg, Jonny (author)
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Riebe, Ilse, 1978 (author)
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- Andersson, My, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Portelius, Erik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Hanse, Eric, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Journal of Alzheimer's disease : JAD. - 1387-2877. ; 16:1, s. 1-14
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Abstract
Subject headings
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- Pathological hallmarks of Alzheimer's disease (AD) include synaptic and neuronal degeneration and the presence of extracellular deposits of amyloid-beta (Abeta) in senile plaques in the cerebral cortex. Although these brain lesions may be seen also in aged non-demented individuals, the increase in brain Abeta is believed by many to represent the earliest event in the disease process. Accumulating evidence suggests that Abeta, which is highly conserved by evolution, may have an important physiological role in synapse elimination during brain development. An intriguing idea is that this putative function can become pathogenic if activated in the aging brain. Here, we review the literature on the possible physiological roles of Abeta and its precursor protein AbetaPP during development with special focus on electrophysiological findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alzheimer Disease
- metabolism
- pathology
- Amyloid beta-Protein
- metabolism
- physiology
- toxicity
- Amyloid beta-Protein Precursor
- metabolism
- physiology
- Animals
- Brain
- growth & development
- Cell Proliferation
- Glutamic Acid
- physiology
- Humans
- Long-Term Potentiation
- physiology
- Memory
- physiology
- Neuronal Plasticity
- physiology
- Synapses
- pathology
- physiology
Publication and Content Type
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- By the author/editor
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Wasling, Pontus
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Daborg, Jonny
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Riebe, Ilse, 197 ...
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Andersson, My, 1 ...
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Portelius, Erik, ...
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Blennow, Kaj, 19 ...
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show more...
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Hanse, Eric, 196 ...
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Zetterberg, Henr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg