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Novel biochemical markers of psychosocial stress in women.

Asberg, Marie (author)
Karolinska Institutet
Nygren, Ake (author)
Karolinska Institutet
Leopardi, Rosario (author)
Karolinska Institutet
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Rylander, Gunnar (author)
Peterson, Ulla (author)
Karolinska Institutet
Wilczek, Lukas (author)
Karolinska Institutet
Källmén, Håkan (author)
Karolinska Institutet
Ekstedt, Mirjam (author)
Karolinska Institutet
Akerstedt, Torbjörn (author)
Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet
Lekander, Mats (author)
Karolinska Institutet
Ekman, Rolf, 1938 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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 (creator_code:org_t)
2009-01-30
2009
English.
In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 4:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women. METHODS: Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women. RESULTS: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill. CONCLUSIONS: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Omvårdnad (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nursing (hsv//eng)

Keyword

Adult
Biological Markers
Chemokine CCL2
blood
Epidermal Growth Factor
blood
Female
Humans
Middle Aged
ROC Curve
Risk Factors
Stress
Psychological
blood
metabolism
psychology
Vascular Endothelial Growth Factor A
blood
Women
psychology
MEDICINE
Hälsovetenskap
Caring sciences

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ref (subject category)
art (subject category)

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