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Novel biochemical m...
Novel biochemical markers of psychosocial stress in women.
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- Asberg, Marie (author)
- Karolinska Institutet
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- Nygren, Ake (author)
- Karolinska Institutet
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- Leopardi, Rosario (author)
- Karolinska Institutet
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Rylander, Gunnar (author)
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- Peterson, Ulla (author)
- Karolinska Institutet
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- Wilczek, Lukas (author)
- Karolinska Institutet
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- Källmén, Håkan (author)
- Karolinska Institutet
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- Ekstedt, Mirjam (author)
- Karolinska Institutet
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- Akerstedt, Torbjörn (author)
- Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet
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- Lekander, Mats (author)
- Karolinska Institutet
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- Ekman, Rolf, 1938 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2009-01-30
- 2009
- English.
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In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 4:1
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Abstract
Subject headings
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- BACKGROUND: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women. METHODS: Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women. RESULTS: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill. CONCLUSIONS: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Keyword
- Adult
- Biological Markers
- Chemokine CCL2
- blood
- Epidermal Growth Factor
- blood
- Female
- Humans
- Middle Aged
- ROC Curve
- Risk Factors
- Stress
- Psychological
- blood
- metabolism
- psychology
- Vascular Endothelial Growth Factor A
- blood
- Women
- psychology
- MEDICINE
- Hälsovetenskap
- Caring sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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PloS one
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Asberg, Marie
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Nygren, Ake
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Leopardi, Rosari ...
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Rylander, Gunnar
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Peterson, Ulla
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Wilczek, Lukas
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show more...
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Källmén, Håkan
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Ekstedt, Mirjam
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Akerstedt, Torbj ...
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Lekander, Mats
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Ekman, Rolf, 193 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nursing
- Articles in the publication
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PloS one
- By the university
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University of Gothenburg
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Stockholm University
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Royal Institute of Technology
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Linnaeus University
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Marie Cederschiöld högskola
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Karolinska Institutet