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Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment.

Brys, Miroslaw (author)
Pirraglia, Elizabeth (author)
Rich, Kenneth (author)
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Rolstad, Sindre, 1976 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Mosconi, Lisa (author)
Switalski, Remigiusz (author)
Glodzik-Sobanska, Lidia (author)
De Santi, Susan (author)
Zinkowski, Ray (author)
Mehta, Pankaj (author)
Pratico, Domenico (author)
Saint Louis, Leslie A (author)
Wallin, Anders, 1950 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
de Leon, Mony J (author)
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 (creator_code:org_t)
Elsevier BV, 2009
2009
English.
In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 30:5, s. 682-90
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • OBJECTIVES: To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD). METHODS: A baseline and 2-year follow-up clinical and CSF study of 86 subjects, including 22 MCI patients that declined to AD (MCI-AD), 43 MCI that did not deteriorate (MCI-MCI) and 21 controls (NL-NL). All subjects were studied for total and phosphorylated tau (T-tau, P-tau(231)), amyloid beta (Abeta) Abeta(42)/Abeta(40) ratio, isoprostane (IP) as well as P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios. RESULTS: At baseline and at follow-up MCI-AD showed higher levels P-tau(231), T-tau, IP, P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios and lower Abeta(42)/Abeta(40) than MCI-MCI or NL-NL. Baseline P-tau(231) best predicted MCI-AD (80%, p<0.001) followed in accuracy by P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios (both 75%, p's<0.001), T-tau (74%, p<0.001), Abeta(42)/Abeta(40) (69%, p<0.01), and IP (68%, p<0.01). Only IP showed longitudinal effects (p<0.05). CONCLUSIONS: P-tau(231) is the strongest predictor of the decline from MCI to AD. IP levels uniquely show longitudinal progression effects. These results suggest the use of CSF biomarkers in secondary prevention trials.

Keyword

Aged
Aged
80 and over
Alzheimer Disease
cerebrospinal fluid
diagnosis
Amyloid beta-Protein
analysis
cerebrospinal fluid
Biological Markers
analysis
cerebrospinal fluid
Cognition Disorders
cerebrospinal fluid
diagnosis
Cohort Studies
Disease Progression
Early Diagnosis
Female
Humans
Isoprostanes
analysis
cerebrospinal fluid
Longitudinal Studies
Male
Middle Aged
Peptide Fragments
analysis
cerebrospinal fluid
Predictive Value of Tests
Prognosis
tau Proteins
analysis
cerebrospinal fluid

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art (subject category)

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