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  • Cesarini, DavidCenter for Experimental Social Science,NYU, Dept Econ, Ctr Expt Social Sci, 550 1St Ave, New York, NY 10003 USA. (author)

Genotype-covariate interaction effects and the heritability of adult body mass index

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-07-10
  • Nature Research (part of Springer Nature),2017

Numbers

  • LIBRIS-ID:oai:hhs.se:1154793180006056
  • https://research.hhs.se/esploro/outputs/journalArticle/Genotype-covariate-interaction-effects-and-the-heritability/991001480298606056URI
  • https://doi.org/10.1038/ng.3912DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333515URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136337997URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and explore the contribution of genotype-covariate interaction effects at common SNP loci. We find evidence for genotype-age interaction (likelihood ratio test (LRT) = 73.58, degrees of freedom (df) = 1, P = 4.83 × 10-18), which contributed 8.1% (1.4% s.e.) to BMI variation. Across eight self-reported lifestyle factors, including diet and exercise, we find genotype-environment interaction only for smoking behavior (LRT = 19.70, P = 5.03 × 10-5 and LRT = 30.80, P = 1.42 × 10-8), which contributed 4.0% (0.8% s.e.) to BMI variation. Bayesian association analysis suggests that BMI is highly polygenic, with 75% of the SNP heritability attributable to loci that each explain <0.01% of the phenotypic variance. Our findings imply that substantially larger sample sizes across ages and lifestyles are required to understand the full genetic architecture of BMI.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm,Stockholm Sch Econ, Stockholm, Sweden.(Swepub:hhs)198@hhs.se (author)
  • Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.,Karolinska Institutet (SE)(Swepub:uu)ering425 (author)
  • Magnusson, Patrik K. E.Karolinska Institutet,Karolinska Institutet (SE) (author)
  • Pedersen, Nancy L.Karolinska Institutet,Karolinska Institutet (SE) (author)
  • Esko, TõnuUniversity of Tartu,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia.;Boston Childrens Hosp, Div Endocrinol, Cambridge, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA. (author)
  • Yang, JianUniversity of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia. (author)
  • Visscher, Peter M.University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia. (author)
  • Robinson, Matthew R.University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland. (author)
  • English, G.University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia. (author)
  • Moser, G.University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia. (author)
  • Lloyd-Jones, LRUniversity of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia. (author)
  • Triplett, MAUniversity of Queensland (AU),Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia.,University of Tartu (author)
  • Zhu, Z.University of Queensland,Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.(Swepub:hhs)s41895@hhs.se (author)
  • Nolte, IMUniversity of Groningen (NL),Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands. (author)
  • van Vliet-Ostaptchouk, JVUniversity of Groningen (NL),Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands.;Univ Groningen, Dept Endocrinol, Univ Med Ctr Groningen, Groningen, Netherlands. (author)
  • Snieder, HUniversity of Groningen (NL),Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands. (author)
  • Milani, LiliUniversity of Tartu,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia. (author)
  • Mägi, ReedikUniversity of Tartu,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia. (author)
  • Metspalu, AndresUniversity of Tartu (author)
  • Center for Experimental Social ScienceNYU, Dept Econ, Ctr Expt Social Sci, 550 1St Ave, New York, NY 10003 USA. (creator_code:org_t)
  • LifeLines Cohort Study

Related titles

  • In:Nature Genetics: Nature Research (part of Springer Nature)49:8, s. 1174-11811061-40361546-1718

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