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Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers : a multinational cohort study

Mayén, Ana-Lucia (author)
International Agency for Research on Cancer, World Health Organization
Aglago, Elom K (author)
International Agency for Research on Cancer, World Health Organization
Knaze, Viktoria (author)
International Agency for Research on Cancer, World Health Organization
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Cordova, Reynalda (author)
Webster Vienna Private University
Schalkwijk, Casper G (author)
Maastricht University Medical Centre
Wagner, Karl-Heinz (author)
Webster Vienna Private University
Aleksandrova, Krasimira (author)
German Institute of Human Nutrition
Fedirko, Veronika (author)
Emory University
Keski-Rahkonen, Pekka (author)
International Agency for Research on Cancer, World Health Organization
Leitzmann, Michael F (author)
University Hospital Regensburg
Katzke, Verena (author)
German Cancer Research Centre
Srour, Bernard (author)
German Cancer Research Centre
Schulze, Matthias B (author)
German Institute of Human Nutrition
Masala, Giovanna (author)
Beatson Institute for Cancer Research
Krogh, Vittorio (author)
Panico, Salvatore (author)
University of Naples Federico II
Tumino, Rosario (author)
Bueno-de-Mesquita, Bas (author)
National Institute for Public Health and the Environment (RIVM)
Brustad, Magritt (author)
UiT The Arctic University of Norway, Tromsø
Agudo, Antonio (author)
Catalan Institute of Oncology-Girona
Chirlaque López, María Dolores (author)
Shanghai Cancer Institute
Amiano, Pilar (author)
Biodonostia Health Research Institute
Ohlsson, Bodil (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
Ramne, Stina (author)
Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
Aune, Dagfinn (author)
Imperial College London
Weiderpass, Elisabete (author)
International Agency for Research on Cancer, World Health Organization
Jenab, Mazda (author)
International Agency for Research on Cancer, World Health Organization
Freisling, Heinz (author)
International Agency for Research on Cancer, World Health Organization
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 (creator_code:org_t)
2021-05-06
2021
English 11 s.
In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 149:4, s. 854-864
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL), and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder, and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer, and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with risk of HCC (per 1 standard deviation [SD] increment, HR-CML =0.87, 95% CI: 0.76 to 0.99, HR-CEL =0.84, 95% CI: 0.74 to 0.96, and HR-MH-G1 = 0.84, 95% CI: 0.74 to 0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML =1.28, 95% CI: 1.05 to 1.56, HR-CEL =1.17; 95% CI: 0.96 to 1.40, HR-MH-G1 =1.27, 95% CI: 1.06 to 1.54). No associations were observed for cancers of the intra- and extra-hepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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