Sibling history is associated with heart failure after a first myocardial infarction

Glinge, CharlotteCopenhagen University Hospital,Academic Medical Center of University of Amsterdam (AMC) (author)

Objective: Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods: Through nationwide registries, we identified all individuals aged 18-50 years hospitalised with first MI from 1997 to 2016 in Denmark. We identified 13 810 patients with MI, and the cohort was followed until HF diagnosis, second MI, 3 years after index MI, emigration, death or the end of 2016, whichever occurred first. HRs were estimated by Cox hazard regression models adjusted for sex, age, calendar year and comorbidities (reference: patients with no family history of MI). Results: After adjustment, we observed an increased risk of MI-induced HF for those having a sibling with MI with HF (HR 2.05, 95% CI 1.02 to 4.12). Those having a sibling with MI without HF also had a significant, but lower increased risk of HF (HR 1.39, 95% CI 1.05 to 1.84). Parental history of MI with or without HF was not associated with HF. Conclusion: In this nationwide cohort, sibling history of MI with or without HF was associated with increased risk of HF after first MI, while a parental family history was not, suggesting that shared environmental factors may predominate in the determination of risk for developing HF.

Oestergaard, LouiseUniversity of Copenhagen,Aalborg University (author)
Jabbari, RezaCopenhagen University Hospital (author)
Rossetti, SaraCopenhagen University Hospital (author)
Skals, RegitzeAalborg University (author)
Køber, LarsCopenhagen University Hospital (author)
Engstrøm, ThomasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital(Swepub:lu)th4331en (author)
Bezzina, Connie R.University of Amsterdam (author)
Torp-Pedersen, ChristianAalborg University (author)
Gislason, GunnarUniversity of Copenhagen,University of Southern Denmark (author)
Tfelt-Hansen, JacobUniversity of Copenhagen,Copenhagen University Hospital (author)
Copenhagen University HospitalAcademic Medical Center of University of Amsterdam (AMC) (creator_code:org_t)

By the author/editor: Glinge, Charlott ...; Oestergaard, Lou ...; Jabbari, Reza; Rossetti, Sara; Skals, Regitze; Køber, Lars; show more...; Engstrøm, Thomas; Bezzina, Connie ...; Torp-Pedersen, C ...; Gislason, Gunnar; Tfelt-Hansen, Ja ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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