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Hypocretin Deficien...
Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy
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Savvidou, Andri (author)
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Knudsen, Stine (author)
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Olsson-Engman, Mia (author)
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Gammeltoft, Steen (author)
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Jennum, Poul (author)
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- Palm, Lars (author)
- Lund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups
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(creator_code:org_t)
- 2013-01-01
- 2013
- English.
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In: Sleep. - : Oxford University Press (OUP). - 0161-8105 .- 1550-9109. ; 36:1, s. 147-148
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http://dx.doi.org/10...
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https://doi.org/10.5...
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Abstract
Subject headings
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- Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- H1N1
- hypocretin deficiency
- narcolepsy
Publication and Content Type
- art (subject category)
- ref (subject category)
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