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  • Bayani, JaneOntario Institute for Cancer Research,University of Toronto (author)

Evaluation of multiple transcriptomic gene risk signatures in male breast cancer

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-07-26
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:020b4257-1f13-4bdf-8e1d-74a43468abee
  • https://lup.lub.lu.se/record/020b4257-1f13-4bdf-8e1d-74a43468abeeURI
  • https://doi.org/10.1038/s41523-021-00301-0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Several multigene assays are increasingly used to guide clinical treatment decisions in female BCa, however, there are limited data on the utility of these tests in male BCa. Here we present the gene expression results of 381 M0, ER+ve, HER2-ve male BCa patients enrolled in the Part 1 (retrospective analysis) of the International Male Breast Cancer Program. Using a custom NanoString™ panel comprised of the genes from the commercial risk tests Prosigna®, OncotypeDX®, and MammaPrint®, risk scores and intrinsic subtyping data were generated to recapitulate the commercial tests as described by us previously. We also examined the prognostic value of other risk scores such as the Genomic Grade Index (GGI), IHC4-mRNA and our prognostic 95-gene signature. In this sample set of male BCa, we demonstrated prognostic utility on univariate analysis. Across all signatures, patients whose samples were identified as low-risk experienced better outcomes than intermediate-risk, with those classed as high risk experiencing the poorest outcomes. As seen with female BCa, the concordance between tests was poor, with C-index values ranging from 40.3% to 78.2% and Kappa values ranging from 0.17 to 0.58. To our knowledge, this is the largest study of male breast cancers assayed to generate risk scores of the current commercial and academic risk tests demonstrating comparable clinical utility to female BCa.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Poncet, CoralieEuropean Organisation for Research and Treatment of Cancer (author)
  • Crozier, CherylOntario Institute for Cancer Research (author)
  • Neven, AnoukEuropean Organisation for Research and Treatment of Cancer (author)
  • Piper, TammyUniversity of Edinburgh (author)
  • Cunningham, CarrieUniversity of Edinburgh (author)
  • Sobol, MonikaUniversity of Edinburgh (author)
  • Aebi, StefanSAKK Coordinating Center (author)
  • Benstead, KimCheltenham General Hospital (author)
  • Bogler, OliverUniversity of Texas (author)
  • Dal Lago, LissandraInstitut Jules Bordet (author)
  • Fraser, Judith (author)
  • Hilbers, FlorentineBreast International Group (author)
  • Hedenfalk, IngridLund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breast and Ovarian Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ifa (author)
  • Korde, LarissaUniversity of Washington (author)
  • Linderholm, BarbroSahlgrenska University Hospital (author)
  • Martens, JohnErasmus University Medical Center (author)
  • Middleton, LaviniaUniversity of Texas (author)
  • Murray, MelissaMemorial Sloan-Kettering Cancer Center (author)
  • Kelly, Catherine (author)
  • Nilsson, Cecilia (author)
  • Nowaczyk, Monika (author)
  • Peeters, Stephanie (author)
  • Peric, AleksandraEuropean Organisation for Research and Treatment of Cancer (author)
  • Porter, PeggyUniversity of Washington (author)
  • Schröder, CarolienUniversity Medical Center Groningen (author)
  • Rubio, Isabel T.Bellvitge University Hospital-IDIBELL (author)
  • Ruddy, Kathryn J.Mayo Clinic Minnesota (author)
  • van Asperen, ChristiLeiden University Medical Centre (author)
  • Van Den Weyngaert, Danielle (author)
  • van Deurzen, CarolienErasmus University Medical Center (author)
  • van Leeuwen-Stok, EliseDutch Breast Cancer Research Group (BOOG) (author)
  • Vermeij, Joanna (author)
  • Winer, EricDana-Farber Cancer Institute (author)
  • Giordano, Sharon H.University of Texas (author)
  • Cardoso, Fatima (author)
  • Bartlett, John M.S.University of Toronto,University of Edinburgh (author)
  • Ontario Institute for Cancer ResearchUniversity of Toronto (creator_code:org_t)

Related titles

  • In:npj Breast Cancer: Springer Science and Business Media LLC7:12374-4677

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