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Guidelines for huma...
Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older
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Meijer, Chris J. L. M. (author)
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Berkhof, Johannes (author)
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Castle, Philip E. (author)
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Hesselink, Albertus T. (author)
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Franco, Eduardo L. (author)
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Ronco, Guglielmo (author)
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Arbyn, Marc (author)
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Bosch, F. Xavier (author)
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Cuzick, Jack (author)
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Heideman, Danielle A. M. (author)
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Snijders, Peter J. F. (author)
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 124:3, s. 516-520
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Abstract
Subject headings
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- Given the strong etiologic link between high-risk HPV infection and cervical cancer high-risk HPV testing is now being considered as an alternative for cytology-based cervical cancer screening. Many test systems have been developed that can detect the broad spectrum of hrHPV types in one assay. However, for screening purposes the detection of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer. Candidate high-risk HPV tests to be used for screening should reach an optimal balance between clinical sensitivity and specificity for detection of high-grade CIN and cervical cancer to minimize redundant or excessive follow-up procedures for high-risk HPV positive women without cervical lesions. Data from various large screening studies have shown that high-risk HPV testing by hybrid capture 2 and GP5+/6+-PCR yields considerably better results in the detection of CIN 2/3 than cytology. The data from these studies can be used to guide the translation of high-risk HPV testing into clinical practice by setting standards of test performance and characteristics. On the basis of these data we have developed guidelines for high-risk HPV test requirements for primary cervical screening and validation guidelines for candidate HPV assays. (C) 2008 Wiley-Liss, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- requirements
- HPV test
- HPV test guidelines
- HPV-DNA testing
- cervical screening
- HPV test statistics
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Meijer, Chris J. ...
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Berkhof, Johanne ...
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Castle, Philip E ...
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Hesselink, Alber ...
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Franco, Eduardo ...
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Ronco, Guglielmo
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show more...
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Arbyn, Marc
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Bosch, F. Xavier
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Cuzick, Jack
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Dillner, Joakim
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Heideman, Daniel ...
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Snijders, Peter ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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International Jo ...
- By the university
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Lund University
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Karolinska Institutet