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Proteomic profiling...
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates
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Dalrymple, Annette (author)
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Wild, Edward J. (author)
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Joubert, Richard (author)
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Sathasivam, Kirupa (author)
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Bjorkqvist, Maria (author)
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- Petersén, Åsa (author)
- Lund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Translational Neuroendocrinology,Lund University Research Groups
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Jackson, Graham S. (author)
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Isaacs, Jeremy D. (author)
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Kristiansen, Mark (author)
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Bates, Gillian P. (author)
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Leavitt, Blair R. (author)
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Keir, Geoff (author)
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Ward, Malcolm (author)
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Tabrizi, Sarah J. (author)
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(creator_code:org_t)
- 2007-06-07
- 2007
- English.
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In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 6:7, s. 2833-2840
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- electrophoresis
- 2D
- proteomics
- neuroinflammation
- Huntington's disease
- plasma
- LC/MS/MS
- MALDI-TOF
- ELISA
- biomarkers
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Dalrymple, Annet ...
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Wild, Edward J.
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Joubert, Richard
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Sathasivam, Kiru ...
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Bjorkqvist, Mari ...
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Petersén, Åsa
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show more...
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Jackson, Graham ...
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Isaacs, Jeremy D ...
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Kristiansen, Mar ...
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Bates, Gillian P ...
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Leavitt, Blair R ...
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Keir, Geoff
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Ward, Malcolm
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Tabrizi, Sarah J ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Journal of Prote ...
- By the university
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Lund University