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- Dalrymple, Annette (author)
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- 2007-06-07
- American Chemical Society (ACS),2007
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:02343b16-69cd-4e97-94a6-b3f1f76d3d39
- https://lup.lub.lu.se/record/646337URI
- https://doi.org/10.1021/pr0700753DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- electrophoresis
- 2D
- proteomics
- neuroinflammation
- Huntington's disease
- plasma
- LC/MS/MS
- MALDI-TOF
- ELISA
- biomarkers
Added entries (persons, corporate bodies, meetings, titles ...)
- Wild, Edward J. (author)
- Joubert, Richard (author)
- Sathasivam, Kirupa (author)
- Bjorkqvist, Maria (author)
- Petersén, ÅsaLund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Translational Neuroendocrinology,Lund University Research Groups(Swepub:lu)mphy-apn (author)
- Jackson, Graham S. (author)
- Isaacs, Jeremy D. (author)
- Kristiansen, Mark (author)
- Bates, Gillian P. (author)
- Leavitt, Blair R. (author)
- Keir, Geoff (author)
- Ward, Malcolm (author)
- Tabrizi, Sarah J. (author)
- Translationell neuroendokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Journal of Proteome Research: American Chemical Society (ACS)6:7, s. 2833-28401535-38931535-3907
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