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Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
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- Carta, Manolo (author)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Neurobiologi,Lund University Research Groups,Neurobiology
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- Carlsson, Thomas (author)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Neurobiologi,Lund University Research Groups,Neurobiology
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- Muñoz, Ana (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
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- (creator_code:org_t)
- 2008
- 2008
- English 14 s.
- In: Progress in Brain Research. - 1875-7855. ; 172, s. 465-478
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Animals
- Clinical Trials as Topic
- Dopamine
- Dyskinesia, Drug-Induced
- Humans
- Levodopa
- Parkinson Disease
- Parkinsonian Disorders
- Presynaptic Terminals
- Protein Isoforms
- Receptors, Dopamine
- Receptors, Serotonin
- Serotonin
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Carta, Manolo
- Carlsson, Thomas
- Muñoz, Ana
- Kirik, Deniz
- Björklund, Ander ...
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
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- Progress in Brai ...
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- Lund University
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