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Neuropeptide Y : pr...
Neuropeptide Y : prejunctional inhibition of vagally induced contractions in the guinea pig trachea
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- Grundemar, L (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Widmark, Erik (author)
- Astra Draco AB
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- Waldeck, B (author)
- Astra Draco AB
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- Håkanson, R (author)
- Lund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 1988
- 1988
- English.
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In: Regulatory Peptides. - : Elsevier BV. - 0167-0115. ; 23:3, s. 309-313
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Abstract
Subject headings
Close
- The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Animals
- Carbachol/pharmacology
- Dose-Response Relationship, Drug
- Electric Stimulation
- Guinea Pigs
- Male
- Muscle Contraction/drug effects
- Muscle, Smooth/drug effects
- Neuropeptide Y/pharmacology
- Trachea/drug effects
- Vagus Nerve/drug effects
Publication and Content Type
- art (subject category)
- ref (subject category)
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