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Genetics of smoking...
Genetics of smoking and risk of clonal hematopoiesis
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- Levin, Michael G. (author)
- University of Pennsylvania,Veterans Health Administration
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- Nakao, Tetsushi (author)
- Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute,Broad Institute,Massachusetts General Hospital
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- Zekavat, Seyedeh M. (author)
- Yale University,Broad Institute
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- Koyama, Satoshi (author)
- Broad Institute
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- Bick, Alexander G. (author)
- Vanderbilt University
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- Niroula, Abhishek (author)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Broad Institute,Dana-Farber Cancer Institute
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- Ebert, Benjamin (author)
- Dana-Farber Cancer Institute,Harvard Medical School,Howard Hughes Medical Institute
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- Damrauer, Scott M. (author)
- University of Pennsylvania,Veterans Health Administration
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- Natarajan, Pradeep (author)
- Massachusetts General Hospital,Broad Institute,Harvard Medical School
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(creator_code:org_t)
- 2022-05-04
- 2022
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been linked to both oncologic and non-oncologic clinical outcomes including atherosclerosis and all-cause mortality. Epidemiologic studies have highlighted smoking as an important driver of somatic mutations across multiple tissues. However, establishing the causal role of smoking in clonal hematopoiesis has been limited by observational study designs, which may suffer from confounding and reverse-causality. We performed two complementary analyses to investigate the role of smoking in mCAs and CHIP. First, using an observational study design among UK Biobank participants, we confirmed strong associations between smoking and mCAs. Second, using two-sample Mendelian randomization, smoking was strongly associated with mCA but not with CHIP. Overall, these results support a causal association between smoking and mCAs and suggest smoking may variably shape the fitness of clones bearing somatic mutations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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