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Carrier detection in hemophilia A : a cooperative international study. II. The efficacy of a universal discriminant
- Green, P P (author)
- Mannucci, P M (author)
- Briët, E (author)
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- Kasper, C K (author)
- Essien, E M (author)
- Chediak, J (author)
- Rizza, C R (author)
- Graham, J B (author)
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- (creator_code:org_t)
- 1986
- 1986
- English.
- In: Blood. - 0006-4971. ; 67:6, s. 7-1560
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Factor VIII (F.VIII) and von Willebrand factor (VWF):Ag data collected by eight laboratories on a total of 336 obligatory carriers of hemophilia A and 137 normal women were used to answer several questions concerning the construction of linear discriminants for carrier detection. It was found: that a "universal" linear discriminant can be constructed which is suitable for use in all laboratories and is nearly as effective as laboratory-specific discriminants; that inclusion of age and ABO blood type data improved the efficacy of these discriminants; that substitution of alternative assays for F.VIII and VWF:Ag did not generally improve the efficacy of the discriminants over that obtained using the bioassay for F.VIII:C and Laurell's immunoassay for VWF:Ag; that linear discriminants were far more effective than discriminants based on the F.VIII:C/VWF:Ag ratio. A step-wise procedure is given which any laboratory may follow in using the universal discriminant for carrier detection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- ABO Blood-Group System
- Adult
- Antigens
- Enzyme-Linked Immunosorbent Assay
- Factor VIII
- Female
- Hemophilia A
- Heterozygote Detection
- Humans
- Immunoenzyme Techniques
- International Cooperation
- Phenotype
- von Willebrand Factor
- Journal Article
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S.
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- art (subject category)
- ref (subject category)
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- Green, P P
- Mannucci, P M
- Briët, E
- Ljung, R
- Kasper, C K
- Essien, E M
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- Chediak, J
- Rizza, C R
- Graham, J B
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- and Hematology
- Articles in the publication
- Blood
- By the university
- Lund University
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