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Risk factors for ex...
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Ahrens, Wolfgang
(author)
Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study
- Article/chapterEnglish2007
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LIBRIS-ID:oai:lup.lub.lu.se:064f758c-eeff-49d9-aaf6-e61d9a85ccd8
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https://lup.lub.lu.se/record/1138539URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable.
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Timmer, Antje
(author)
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Vyberg, Mogens
(author)
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Fletcher, Tony
(author)
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Guenel, Pascal
(author)
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Merler, Enzo
(author)
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Merletti, Franco
(author)
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Morales, Maria
(author)
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Olsson, HåkanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol
(author)
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Olsen, Jorn
(author)
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Hardell, Lennart
(author)
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Kaerlev, Linda
(author)
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Raverdy, Nicole
(author)
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Lynge, Elsebeth
(author)
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Bröstcancer-genetikSektion I
(creator_code:org_t)
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In:European Journal of Gastroenterology and Hepathology19:8, s. 623-6301473-5687
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Ahrens, Wolfgang
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Timmer, Antje
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Vyberg, Mogens
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Fletcher, Tony
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Guenel, Pascal
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Merler, Enzo
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show more...
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Merletti, Franco
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Morales, Maria
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Olsson, Håkan
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Olsen, Jorn
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Hardell, Lennart
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Kaerlev, Linda
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Raverdy, Nicole
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Lynge, Elsebeth
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- MEDICAL AND HEALTH SCIENCES
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and Gastroenterology ...
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Lund University