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Rapid test for lung...
Rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted respiratory distress syndrome with high sensitivity
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- Verder, Henrik (author)
- Holbaek University Hospital, Denmark
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- Heiring, Christian (author)
- University of Copenhagen, Denmark
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- Clark, Howard (author)
- University of Southampton, England
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- Sweet, David (author)
- Royal Jubilee Maternity Hospital,Royal Matern Hospital, North Ireland
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- Jessen, Torben E. (author)
- Holbaek University Hospital, Denmark
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- Ebbesen, Finn (author)
- Aalborg University, Denmark
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- Björklund, Lars J. (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden; Lund University, Sweden
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- Andreasson, Bengt (author)
- Skåne University Hospital, Lund, Sweden
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- Bender, Lars (author)
- Aalborg University, Denmark
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- Bertelsen, Aksel (author)
- Holbaek University Hospital, Holbaek, Denmark
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- Dahl, Marianne (author)
- Odense University Hospital,University of Southen, Denmark
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- Eschen, Christian (author)
- Holbaek University Hospital, Holbaek, Denmark
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- Fenger-Grøn, Jesper (author)
- University of Soouthern, Denmark
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- Hoffmann, Stine F. (author)
- University of Copenhagen, Denmark
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- Höskuldsson, Agnar (author)
- Holbaek University Hospital, Denmark
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- Bruusgaard-Mouritsen, Maria (author)
- Holbaek University Hospital, Denmark
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- Lundberg, Fredrik (author)
- Linköpings universitet,Linköping University,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Postle, Anthony D. (author)
- Southampton General Hospital,University of Southampton, England
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- Schousboe, Peter (author)
- Holbaek University Hospital, Denmark
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- Schmidt, Peter (author)
- University of Copenhagen, Denmark
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- Stanchev, Hristo (author)
- Naestved University Hospital, Denmark
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- Sørensen, Lars (author)
- Holbaek University Hospital, Denmark
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(creator_code:org_t)
- 2016-12-20
- 2017
- English.
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In: Acta Paediatrica, International Journal of Paediatrics. - : Wiley. - 0803-5253 .- 1651-2227. ; 106:3, s. 430-437
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Aim: Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation. Methods: Concentrations of the most surface-active lung phospholipid dipalmitoylphosphatidylcholine and sphingomyelin in gastric aspirates from premature infants were measured by mass spectrometry and expressed as the lecithin/sphingomyelin ratio (L/S). The same aspirates were analysed with mid-infrared spectroscopy. Subsequently, L/S was measured in gastric aspirates and oropharyngeal secretions from another group of premature infants using spectroscopy and the results were compared with RDS development. The 10-minute analysis required 10 μL of aspirate. Results: An L/S algorithm was developed based on 89 aspirates. Subsequently, gastric aspirates were sampled in 136 infants of 24-31 weeks of gestation and 61 (45%) developed RDS. The cut-off value of L/S was 2.2, sensitivity was 92%, and specificity was 73%. In 59 cases, the oropharyngeal secretions had less valid L/S than gastric aspirate results. Conclusion: Our rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted RDS with high sensitivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Gastric aspirate
- Lung surfactant
- Mid-infrared spectroscopy
- Prematurity
- Respiratory distress syndrome
- Gastric aspirate; Lung surfactant; Mid-infrared spectroscopy; Prematurity; Respiratory distress syndrome
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Verder, Henrik
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Heiring, Christi ...
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Clark, Howard
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Sweet, David
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Jessen, Torben E ...
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Ebbesen, Finn
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show more...
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Björklund, Lars ...
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Andreasson, Beng ...
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Bender, Lars
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Bertelsen, Aksel
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Dahl, Marianne
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Eschen, Christia ...
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Fenger-Grøn, Jes ...
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Hoffmann, Stine ...
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Höskuldsson, Agn ...
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Bruusgaard-Mouri ...
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Lundberg, Fredri ...
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Postle, Anthony ...
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Schousboe, Peter
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Schmidt, Peter
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Stanchev, Hristo
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Sørensen, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Acta Paediatrica ...
- By the university
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Lund University
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Linköping University